中国畜牧兽医2011，Vol.38Issue(11)：66-69,4.
羟丙基-β-环糊精包合甲氧苄啶的研究
Study on Inclusion of Trimethoprim with Hydroxypropyl-β-cyclodextrin
摘要
Abstract
To investigate the inclusion of Trimethoprim (TMP) with Hydroxypropyl-β- cyclodextrin (HP-β-CD) in aqueous soliut-ions, change of thermodynamic parameters during the inclusion process and inclusion molar ratio of the host and guest molecules. The measurements of apparent inclusion constant of TMP with HP-β-CD, the change of entropy, enthalpy and free energy of the reaction, inclusion molar ratio were carried out by the following methods separately were phase solubility method,equimolar series method andmolar ratio method, respectively. That all the phase solubility diagrams showed a typical AL-type in various temperature aqueous solutions, suggested the formation of a inclusion complex of 1 ' 1 molar ratio. The change in the thermodynamic parameters suggested that the inclusion could proceed spontaneously along with the release of heat and the increase of entropy. An 1 : 1 molar ratio inclusion complex of TMP with HP-β-CD could be formed spontaneously and the solubility of TMP in aqueous solution increased. Appropriate temperature probably favor the progress of inclusion procedure.关键词
甲氧苄啶/羟丙基-β-环糊精/包合常数/热力学参数/包合比Key words
Trimethoprim/ Hydroxypropyl-β-cyclodextrin/ inclusion constant/ inclusion molar ratio/ thermodynamic parameters分类
医药卫生引用本文复制引用
张伟,符华林,陈静,姜彪,舒刚,付强..羟丙基-β-环糊精包合甲氧苄啶的研究[J].中国畜牧兽医,2011,38(11):66-69,4.基金项目
教育部《长江学者和创新团队发展计划》创新团队项目(IRTO848). （IRTO848）
