中国畜牧兽医2011，Vol.38Issue(11)：116-120,5.
拷贝数变异及其在畜禽中的研究进展
Copy Number Variation and its Research in Livestock and Poultry
摘要
Abstract
Single nucleotide polymorphisms (SNPs) have been always the focus of most molecular biologists. However,the core of genome research in organism is to understand the molecular mechanisms of phenotypic differences so that a complete understanding of all the kinds of variations is necessary besides SNPs. Copy number variations (CNVs) are DNA segments ranging from kb to Mb. Many of CNVs are big enough to encompass whole genes so that they are more likely to affect organis-mal fitness compared to SNPs. There are now multiple studies demonstrating a strong link between copy-number differences at specific genes and phenotypic differences. In this paper,we review the outline of CNVs,focusing on the methods used to detect them and the molecular mechanisms responsible for generating this type of variation. In addition,research of CNVs in livestock and poultry was introduced.关键词
拷贝数变异/单核苷酸多态性/畜禽Key words
copy number variations/ single nucleotide polymorphisms/ livestock and poultry分类
农业科技引用本文复制引用
严林俊,唐星,孙涛..拷贝数变异及其在畜禽中的研究进展[J].中国畜牧兽医,2011,38(11):116-120,5.基金项目
江苏省南通市科技产业化计划(农业)项目(CL2009002) （农业）
江苏省高等学校大学生实践创新训练计划项目. （）
