中国畜牧兽医2011，Vol.38Issue(11)：188-190,3.
5种伊维菌素注射液在家兔体内的比较药动学研究
Compare Pharmacokinetics of 5 Different Ivermectin Injection in Rabbit
摘要
Abstract
The pharmacokinetics was investigated and compared in 50 healthy rabbits following single subcutaneous (5 mg/ kg body weight) administration of 5 different ivermectin injection. The ivermectin concentrations in plasma samples were determined by HPLC-UV. Pharmacokinetic analysis of plasma drug concentration-time data for ivermectin was carried out with a computer program 3P97. The ivermectin concentration-time data were fitted to one-compartment open model after single subcutaneous administration of ivermectin injection. The main pharmacokinetics parameters(E) were as T1/2(ka) (8. 10±3. 68)h, T1/2(Ke)(36. 34±14. 63) h,Tmax(22. 38±8. 63) h,Cmax(354. 01 ±57. 75) ng/mL, AUC(25843±3029) ng/(mL · H). The statistics analyzed by SPSS results showed there were no significant differences (P>0. 05) in T1/2(ka) ,T1/2(Ke). However, pharmacokinetic of Cmax was significant differences (P<0. 05). Pharmacokinetics of AUC was higher than others, the results of present studies showed that the ivermectin injection demonstrated rapid absorption, rapid elimination, highly bioavailability. The safety of ivermectin in rabbits indicated that ivermectin injection satisfied clinical requirements eluded that supplementation of bacillus preparation in diets increased the antioxidant capacity and improve intestine microbial flora of layers.关键词
伊维菌素/生物利用度/药代动力学/家兔Key words
ivermectin/ bioavailability/ pharmacokinetics/ rabbits分类
农业科技引用本文复制引用
张瑞丽,崔亮亮,郝智慧,赵永达..5种伊维菌素注射液在家兔体内的比较药动学研究[J].中国畜牧兽医,2011,38(11):188-190,3.基金项目
国家火炬计划"新型系列动物药物产业化项目"(2008GH021319). （2008GH021319）
