中国循证儿科杂志2012，Vol.7Issue(2)：107-112,6.DOI:10.3969/j.issn.1673-5501.2012.02.006
肾小球系膜区IgM沉积在儿童原发性肾小球疾病中的意义
The significance of mesangial IgM deposition in childhood primary glomerulopathy
朱碧溱 1丁洁1
作者信息
- 1. 北京大学第一医院儿科,北京,100034
- 折叠
摘要
Abstract
Objectives To explore the significance of mesangial IgM deposition in childhood primary glomerulopathy. Methods Clinical and renal pathological data were collected from patients with childhood primary glomerular diseases who had undergone renal biopsies at Peking University First Hospital from June 2005 to June 2011. Patients were divided into two groups: IgM deposit group comprised patients with mesangial IgM deposits and control group comprised patients without mesangial IgM deposits. A retrospective analysis was carried out on all children who met the criteria. Results Of the 618 children with renal biopsy speciments, 125 children met both clinical and pathologic diagnosis. IgM deposit group included 76 cases, while control group contained 49 cases. There was no difference between the two groups in disease onset age, incidence of hypertension, renal insufficiency, serum total protein, serum albumin, serum cholesterol, CCr or kidney early injury parameters. Serum IgM was significantly higher in IgM deposition group than that in control group ( P = 0. 038 ). Proteinuria in IgM deposit group was significantly more severe than that in control group ( P = 0. 025 ). IgM deposit group had a significantly higher incidence of glomerular sclerosis and arteriole injury than control group ( P = 0. 002, 0. 039 ). Whereas the occurrence of glomerulopathy basement membrane thickness in IgM deposit group was significantly lower than that in control group( P = 0. 000 ). There was no significant difference between the two groups when comparing the response to steroid treatment. During the follow-up period, there was no significant difference in the incidence of renal insufficiency between the two groups. Conclusions The childhood primary glomerulopathy with mesangial IgM deposits has more severe proteinuria and pathological changes than that without mesangial IgM deposits. More attention should be paid on patients with mesangial IgM deposits and the possible histological transition to focal segmental glomerulosclerosis.关键词
IgM沉积/原发性肾小球疾病/儿童/IgM肾病/局灶节段性肾小球硬化Key words
IgM deposits/Primary glomerulopathy/Childhood/IgM nephropathy/Focal segmental glomerulosclerosis引用本文复制引用
朱碧溱,丁洁..肾小球系膜区IgM沉积在儿童原发性肾小球疾病中的意义[J].中国循证儿科杂志,2012,7(2):107-112,6.
