摘要
Abstract
OBJECTIVE: To study the correlation between the quantity of the antibiotics used yearly and the drug resistance of extended-spectrum β-lactamases (ESBLs)producing Escherichia coli. METHODS: The yearly quantity (DDDs) of the antibacterials prescribed for patients from 2004 to 2010 and drug resistance of ESBLs producing E. Coli were investigated retrospectively. The correlation between the DDDs of 6 kinds of drugs and drug resistance of ESBLs producing E. Coli were analyzed using Spearman correlation analysis of SPSS 13.0 software. RESULTS: The quantity of amikacin was positively correlated with drug resistance of E. Coli to amikacin, aztreonam, cefoperazone/sulbactam and ceftazidime (r=0.821,0.821,0.857,0.893,P<0.05); drug resistance of E. Coli to amikacin was positively correlated with drug resistance of ￡ coli to aztreonam, cefoperazone/sulbactam and ceftazidime (r=0.786, 0.946, 0.929,P<0.05); drug resistance of E. Coli to ceftazidime was positively correlated with drug resistance of E. Coli to aztreonam, cefoperazone/sulbactam (r=0.929, 0.857,P<0.05). CONCLUSION: The increase of antibacterial drugs lead to the increase of ESBLs producing strain, so bacterial strains have drug resistance to various antibacterial drugs, or multiple resistance. Therefore, we should pay attention to control the frequency of antibacterial drug use and prevent to produce ESBLs producing strains.关键词
抗菌药物/用药频度/超广谱β-内酰胺酶大肠埃希菌/耐药率/相关性Key words
Antibacterial drugs/ DDDs/ Extended-spectrum β-lactamases producing Escherichia coli/ Drug resistance/Correlation分类
医药卫生
