中国药房2011，Vol.22Issue(46)：4379-4382,4.
沙利度胺治疗严重复发性阿弗他溃疡的系统评价
Systematic Review of Thalidomide for Severe Recurrent Aphthous Ulcer
杨敏 1牟金金 2周俊翔 1柳汝明 2唐尧1
作者信息
- 1. 四川大学华西医院药剂科,成都市610041
- 2. 四川大学华西药学院,成都市610041
- 折叠
摘要
Abstract
OBJECTIVE: To evaluate the therapeutic efficacy and safety of thalidomide for severe recurrent aphthous ulcer (RAU). METHODS: All relative literatures were searched systematically and screened according to the inclusion criteria. Included studies were evaluated critically and Meta-analysis was conducted. RESULTS: Meta-analysis reveals that there was significant difference in effectiveness between 2 groups (P<0.000 1). By different dose, Meta-analysis of higher dose sub-group indicated there was significant difference between 2 groups (/><0.000 1); while lower dose sub-group indicated there was no significant difference between 2 groups (P=0.48). There was significant difference in serious adverse drug reaction between 2 groups(P=0.000 4); statistical significant difference was revealed in the incidence of somnolence (P< 0.000 l)and rash (P= 0.000 1); difference was not significant statistically in neuropathy (P=0.18) and nausea (P=0.15). CONCLUSION: Thalidomide can effectively contribute to the recovery of severe RAU while it is poor in safety. It should be applied to a proper indication with appropriate dosage.关键词
沙利度胺/复发性阿弗他溃疡/系统评价/荟萃分析Key words
Thalidomide/ Recurrent aphthous ulcer/ Systematic review/ Meta-analysis分类
医药卫生引用本文复制引用
杨敏,牟金金,周俊翔,柳汝明,唐尧..沙利度胺治疗严重复发性阿弗他溃疡的系统评价[J].中国药房,2011,22(46):4379-4382,4.
