中国药房2011，Vol.22Issue(46)：4384-4386,3.
右美托咪定对阻塞性睡眠呼吸暂停综合征患者腭咽成型术后睡眠功能的影响
Effect of Dexmedetomidine on Sleeping Function in Patients with Obstructive Sleep Apnea Syndrome Undergoing Uvulopalatopharyngoplasty
徐意钗 1蒋宗明 1仲俊峰 1陈忠华1
作者信息
- 1. 浙江绍兴市人民医院麻醉科,绍兴市312000
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the effect of dexmedetomidine on sleeping function in patients with obstructive sleep apnea syndrome (OSAS) undergoing uvulopalatopharyngoplasty (UPPP). METHODS: 147 OSAS patients undergoing selective UPPP were enrolled and divided into group C (n=70) and group D (n=77). In group D, patients received intravenous infusion of dexmedetomidine 0.35 μg·kg-1·h-1 after anesthesia induction and terminated 30 min before the completion of surgery; the other treatments were the same in 2 groups. Hemodynamics data were recorded at corresponding time points and Polysomnography monitoring was instituted after admission to the ward. RESULTS: The time of spontaneous awake, time of endotracheal extubation and amount of intra-operative additional amount of fentanyl in group D were significantly decreased, compared with group C (P< 0.01). The heart rate-systolic blood pressure product (RPP) in group D were markedly lower than in group C at T1, T2, T3, T4 and T5 (P<0.01). Results of polysomnography indicated that in group D apnea hypoventilation index was decreased, the lowest pulse oxygenation saturation was increased, and proportions of stage 3~4 sleep and rapid eye movement sleep were elevated (P<0.05 or P<0.01). CONCLUSION: The application of dexmedetomidine in the UPPP operation of OSAS patients can decrease the use of opioid, fentanyl for example, display a protective effect on respiration management in OSAS patients, reduce the risk after operation and improve sleeping function.关键词
右美托咪定/阻塞性睡眠呼吸暂停综合征/腭咽成型术/睡眠功能Key words
Dexmedetomidine/ Obstructive sleep apnea syndrome/ Uvulopalatopharyngoplasty/ Sleeping function分类
医药卫生引用本文复制引用
徐意钗,蒋宗明,仲俊峰,陈忠华..右美托咪定对阻塞性睡眠呼吸暂停综合征患者腭咽成型术后睡眠功能的影响[J].中国药房,2011,22(46):4384-4386,3.
