中国药房2011，Vol.22Issue(46)：4391-4393,3.
TACE联合FOLFOX4方案治疗中晚期肝细胞癌的临床观察
Clinical Observation of FOLFOX4 Adjuvant Chemotherapy Combined with Transcatheter Arterial Chemoembolization in the Treatment of Advanced Hepatocellular Carcinoma
何兴平 1高云 1杨胜利1
作者信息
- 1. 四川攀枝花市中心医院,攀枝花市617067
- 折叠
摘要
Abstract
OBJECTIVE: To observe the therapeutic efficacy and adverse drug reaction of FOLFOX4 combined with transcatheter arterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma. METHODS: 37 patients with advanced hepatocellular carcinoma, who were admitted to our hospital from Jul. 2010 to Jan. 2011, were analyzed retrospectively. Transcatheter arterial chemoembolization (TACE) was performed at least twice for each patient. FOLFOX4 adjuvant chemotherapy was given after TACE procedure: oxaliplatin at the dose of 85 mg·m-2, intravenous drip infused for 2 hours at the first day of treatment; calcium folinate at the dose of 200 mg·m-2 intravenous drip infused for 2 hours at the first and the second day of treatment; 5-fluorouracil at the dose of 600 mg·m-2, intravenous drip infused for 22 hours after intravenous push with the dose of 400 mg · m-2 at the first and the second day of treatment. Therapy was repeated every 3 weeks. The efficacy and adverse drug reactions were evaluated after half year' s follow-up. RESULTS: The overall response rate was 48.6% , and the disease control rate was 81.1%. Adverse drug reactions were grade I to HI , released after corresponding treatments. CONCLUSION: FOLFOX4 adjuvant chemotherapy combined with TACE is optimal in the treatment of advanced hepatocellular carcinoma in effective rate and disease control rate, with tolerable side effects.关键词
肝细胞癌/FOLFOX4/经导管肝动脉化疗栓塞术Key words
Hepatocellular carcinoma/ FOLFOX4/ Transcatheter arterial chemoembolization分类
医药卫生引用本文复制引用
何兴平,高云,杨胜利..TACE联合FOLFOX4方案治疗中晚期肝细胞癌的临床观察[J].中国药房,2011,22(46):4391-4393,3.
