中国药房2011，Vol.22Issue(47)：4425-4427,3.
余甘子提取物对尿酸钠诱导大鼠急性痛风性关节炎的作用研究
Effects of Different Extracts of Phyllanthus emblica on Sodium Urate-induced Acute Gouty Arthritis in Rats
摘要
Abstract
OBJECTIVE: To study the effects of different extract parts from Phyllanthus emblica on acute gouty arthritis in rats. METHODS: Rats were divided into blank control group, model group, colchicine group and methanol extracts group, petroleum ether part group, ethyl acetate part group, n-butyl alcohol part group, water-phase part group of P. embilica. Gouty arthritis model of rat was induced by sodium urate in above groups. The swelling degree of joint, gait, the contents of PEG2 and serum TNF-α were observed and determined. The effects of different extract parts from P. emblica on gouty arthritis were investigated. RESULTS: Compared with model group, the swelling degree of ankle joint of methanol extracts of P. emblica group, ethyl acetate part group, n-butyl alcohol part group and water-phase part group decreased significantly(P<0.05).Gain score of each extracts group decreased significantly (P<0.05).PEG2 content of methanol extracts of P. emblica group, ethyl acetate part group, petroleum benzine group, n-butyl alcohol part group decreased significantly (P< 0.05).TNF-α content of acetic ether group, n-butanol group, petroleum benzine group also decreased significantly(P<0.05). CONCLUSION: Ethyl acetate part and n-butyl alcohol part of the extracts of P. emblica show obvious anti-inflammatory and analgesic effect on gouty arthritis in rats. The mechanism of relieving inflammation reaction is to inhibit the release of PGE2 and TNF-α in local tissue and serum.关键词
余甘子/提取部位/痛风性关节炎/大鼠Key words
Phyllanthus emblica/ Extract parts/ Gouty arthritis/ Rat分类
医药卫生引用本文复制引用
岑志芳,张继平,李海燕,曾煦欣,吴剑峰..余甘子提取物对尿酸钠诱导大鼠急性痛风性关节炎的作用研究[J].中国药房,2011,22(47):4425-4427,3.基金项目
建设中医药强省科研立项资助课题(2009056) （2009056）
