摘要
Abstract
OBJECTIVE: To explore the effect of atorvastatin on blood lipids and plasma inflammatory cytokines in patients with unstable angina. METHODS: 64 cases of unstable angina patients were randomly divided into atorvastatin group and control group. 2 groups of patients after admission in accordance with unstable angina treatment regimens for treatment, atorvastatin group based on those and combined with atorvastatin 20 mg-d～' every night before bed, oral, 8 weeks. RESULTS:atorvastatin group after 8 weeks, TC, TG, LDL-C level than before treatment was significantly decreased(p<0.05), HDL-C level increased significantly compared with those before treatment (P<0.05), while the control group before and after treatment in both groups showed no significant change(P>0.05). 2 groups of hs-CRP and TNF-a level than before treatment was significantly decreased(P<0.05 or P< 0.01), and the effects of atorvastatin group than in the control group decreased more obviously (P< 0.05). CONCLUSION: Atorvastatin has lipid-lowering, anti-inflammatory effect, can improve the blood vessels within the plaque inflammation, has good cardiovascular protective effect.关键词
阿托伐他汀/不稳定型心绞痛/血脂/超敏C反应蛋白/肿瘤坏死因子-αKey words
Atorvastatin/Unstable angina/Blood lipid/High sensitive C-reactive protein/Tumor necrosis factor-a分类
医药卫生
