中国药房2012，Vol.23Issue(1)：59-61,3.DOI:10.6039/j.issn.1001-0408.2012.01.21
正交试验优化复方奥硝唑阴道生物黏附膜处方
Optimization of the Formulation of Compound Ornidazole Chitosan Vaginal Bioadhesive Film by Orthogonal Experiment
王利 1王法琴 1王立宏 2刘铭佩 1焦海胜1
作者信息
- 1. 兰州大学第二医院药剂科,兰州730030
- 2. 甘肃武威市医院,甘肃 武威733000
- 折叠
摘要
Abstract
OBJECTIVE: To optimize the formulation of Compound ornidazole chitosan vaginal bioadhesive film. METHODS: The formulation was optimized by orthogonal design with the chitosan concentration, gelatin concentration, PVA concentration and drug concentration as factors using vertical force as index. The bioadhesiveforce and in vitro drug release rate of the films were measured as well. RESULTS: The optimum formulation was as follows: chitosan 2.0%, gelatin 1.0%, PVA 1.0% and drug 2.0%. The average bioadhesiveness of 3 batches of optimized preparations was 2.1 N·cm-2, and the in vitro drug release rate of the films in 12 h was more than 89%. CONCLUSION: The optimal Compound ornidazole chitosan vaginal bioadhesive film shows proper bio-adhesion force and slow-release character.关键词
奥硝唑/壳聚糖/阴道生物黏附膜/正交试验/处方优化Key words
Ornidazole/ Chitosan/ Vaginal bioadhesive film/ Orthogonal experiment/ Formulation optimization分类
医药卫生引用本文复制引用
王利,王法琴,王立宏,刘铭佩,焦海胜..正交试验优化复方奥硝唑阴道生物黏附膜处方[J].中国药房,2012,23(1):59-61,3.
