中国药房2012，Vol.23Issue(5)：400-402,3.DOI:10.6039/j.issn.1001-0408.2012.05.06
肿瘤辐射增敏剂尼可胺的一般药理学研究
Study on General Pharmacology of Tumor Radio-sensitization Agent Nikean
摘要
Abstract
OBJECTIVE: To study general pharmacology of tumor radio-sensitization agent nikean. METHODS:Mice were randomized into solvent control group, nikean high-dose, medium-dose and low-dose groups (375 mg·kg-1 750 mg·kg-1, 1 500 mg-kg"'), respectively with 10 mice in each group. Those groups were administered with relevant medicine via tail intravenous vein. The free action and balance capacity of mice were investigated. Experimented dogs were also divided into solvent control group, nikean high-dose, medium-dose and low-dose groups (180 mg·kg-1, 360 mg·kg-1, 540'mg·kg-1) groups, respectively with 6 dogs in each group. Those dogs were administered with relevant medicine via buttock intravenous vein. The blood pressures, electrocardiogram, heart rate, heart rhythm, and breathing rate and depth in anaesthesized dogs were also investigated. RESULTS Compared with solvent control group, nikean groups had no obvious change in free action and' balance capacity of mice. Nikean high-dose group had some decline in above two indexes. Nikean groups had no obvious change in blood pressure, electrocardiogram, heart rate, heart rhythm, respiratory frequency and depth of anaesthesized dogs. CONCLUSION:Nikean 1 500 nig·kg-1 has some impact on central nervous system in mice, but unobviously. Under this experimental condition, nikean has no impact on physiological functions of cardiovascular and respiratory system in dogs.关键词
辐射增敏剂/尼可胺/一般药理学/小鼠/犬Key words
Radio-sensitization agent/ Nikean/ General pharmacology/ Mice/ Dogs分类
医药卫生引用本文复制引用
周则卫,沈秀,韩英,唐卫生,杨娜,刘晓秋..肿瘤辐射增敏剂尼可胺的一般药理学研究[J].中国药房,2012,23(5):400-402,3.基金项目
天津市科技计划项目(09ZCKFSH01500) （09ZCKFSH01500）
