中国药房2012，Vol.23Issue(6)：501-504,4.DOI:10.6039/j.issn.1001-0408.2012.06.07
我院2006-2010年抗菌药物应用与细菌耐药相关性分析
Analysis of the Correlation between Antibiotic Use and Drug Resistance in Our Hospital from 2006 to 2010
孙源 1穆殿平 1徐彦贵 1张坚磊2
作者信息
- 1. 天津市第一中心医院药剂科,天津300192
- 2. 天津市第一中心医院检验科,天津300192
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the correlation between the antibiotic use and drug resistance, and to provide theoretic basis for reducing drug resistance and the incidence of nosocomial infection. METHODS: The category and consumption sum of antibiotics in the inpatients from 2006 to 2010 were collected from HIS, and the information of pathogen infection was collected from the laboratory department. Bacteriological examination and drug resistance of the corresponding period were analyzed, and the clinical isolates of common pathogens and drug resistance data were selected. WHONET 5.6 software was used for data statistics and processing. RESULTS: During 5 years, the DDDs of antibiotic had correlation with Escherichia coli producing ESBLs(r=0.900 2, /><0.05); the DDDs of cephalosporins and drug resistance of Gram-negative bacteria had significant correlation (r=0.900 4,P< 0.05); the DDDs of quinolones also had correlation with drug resistance of Gram-negative bacteria (r=0.965 4,/><0.05) , especially with the drug resistance of Escherichia coli in decreasing tendency yearly, it was significantly correlated with the DDDs of quinolones (r=0.913 5,P<0.05). CONCLUSIONS: The DDDs of antibiotic has correlation with bacterial resistance. So rational use of antibiotic can reduce or prevent drug resistance and reduce nosocomial infection.关键词
耐药性/用药频度/合理应用/相关性Key words
Drug resistance/ DDDs/ Rational use/ Correlation分类
医药卫生引用本文复制引用
孙源,穆殿平,徐彦贵,张坚磊..我院2006-2010年抗菌药物应用与细菌耐药相关性分析[J].中国药房,2012,23(6):501-504,4.
