中国药房2012，Vol.23Issue(9)：788-790,3.DOI:10.6039/j.issn.1001-0408.2012.09.07
异长春花碱脂质体的制备及其在小鼠体内的组织分布
Preparation of Vinorelbine Liposomes and Their Tissue Distribution in Mice
摘要
Abstract
OBJECTIVE: To prepare Vinorelbine liposomes (VRB) and to investigate their tissue distribution in mice. METHODS: Vinorelbine liposomes were prepared by film-dispersion method. Lewis lung carcinoma C57BL/6J tumor-bearing mice were divided into control group (VRB injection) and liposomes group (VRB liposomes) with each group of 24 mice. Those mice were given relevant medicine 10 mg·kg-1 via tail vein. Sampling was scheduled at 0.5, 2.0 and 12.0 h, and HPLC method was performed to determine the drug concentration in plasma, heart, liver, spleen, lung, kidney, muscle, brain and tumor. The drug targeting index was computed finally. RESULTS: Mean particle size of VRB liposomes was 158.3 nm. VRB liposomes were complete round in appearance and uniform in size with obvious bi-layer. Compared with control group, Vinorelbine liposomes were distributed mainly in liver, spleen and tumor in mice (P＜0.05 or P<0.01). No obvious change was found in other tissues. Obvious targeting of VRB liposomes to liver, spleen, tumor and some targeting of it to lung were observed. CONCLUSIONS: Prepared VRB liposomes have obvious targeting to the tumor of lung carcinoma model mice.关键词
异长春花碱/脂质体/制备/C57BL/6J荷瘤小鼠/组织分布Key words
Vinorelbine /Liposome/ Preparation/ C57BL/6J tumor-bearing mice/ Tissue distribution分类
医药卫生引用本文复制引用
李学涛,赵琳,程岚..异长春花碱脂质体的制备及其在小鼠体内的组织分布[J].中国药房,2012,23(9):788-790,3.基金项目
国家自然科学基金资助项目(81102822) （81102822）
