摘要
Abstract
Objective To evaluate the treatment outcome of both late-couise accelerated hypeifractionated three-dimensional conformal radiotherapy (LCAH3DCRT) and late-course accelerated hyperrractionated radiotherapy (LCAHRT) for esophageal carcinoma. Methods 56 esophageal carcinoma patients were divided randomly into two groups. Both groups underwent conventional radiotherapy of 40 Gy with virtual simulation planning during the first two-third of the treatment period. During the remaining one-third of the treatment period,the 28 patients in LCAH3DCRT were treated with LCAH3DHRT of 20-28 Gy, 1.6 Gy/session,twice a day,5 days a week,and a total dose of 60-68 Gy in 33-40 sessions over 37-40 days;the 28 patients in the LCAHRT group were treated with LCAHRT of the same dose as that of the LCAH3DHRT group. Results The 5-year survival rate was 31% and 22% in LCAH3DCRT and LCAHRT group,respectively (P=0.028). The 3-,4-and 5-year tumor-free survival rate was 34%,32%,31% and 28%,26%,21% in LCAH3DCRT and LCAHRT group,respectively (all P< 0.05). The 1-,2-,3-,4-,and 5-year local control rate was 78%, 73%,61%,59%,56% and 58%,37%,30%,28%,25% in LCAH3DCRT and LCAHRT group,respectively ( all P< 0.05). Conclusion LCAH3DCRT increased both the 5-year survival and loca control rate and should be chosen over LCAHRT for the treatment of esophageal carcinoma.关键词
放射剂量分次,适形/食管肿瘤/放射疗法Key words
dosage/ conformal/ esophageal carcinoma/ radiotherapy分类
医药卫生
