中国医科大学学报2011，Vol.40Issue(12)：1131-1133,3.DOI:21-1227/R.20111226.1613.015
正常皮肤组织和病理性瘢痕中转化生长因子β1及β-连环蛋白基因的表达
The Gene Expression and Significance of Transforming Growth Factor-β1 and β-catenin in Pathological Scar
耿祎楠 1郭澍 1程铭2
作者信息
- 1. 中国医科大学附属第一医院整形外科,沈阳110001
- 2. 中国医科大学公共卫生学院卫生毒理学教研室,沈阳110001
- 折叠
摘要
Abstract
Objective To study the gene expression of transforming growth factor-β1 (TGF-β1) and β-catenin and to explore their effects in pathological scars. Methods RT-PCR techniques were used to detect the gene expression of TGF-β1 and β-catenin in 22 case of keloid, 29 cases of hypertrophic scar and 18 cases of normal skin, and statistics was used to analyze the data. Results The gene expression of TGF-β1 and β1-catenin in keloid and hypertrophic scar were stronger than that in normal skin and there were significant differences between them (P < 0.01). But gene expression was not statistically difference between keloid scar and hypertrophic scar (P > 0.05). Conclusion TGF-p/smad and Wnt/β-catenin signal pathway might promote the formation of the pathological scar.关键词
转化生长因子β1/β连环蛋白/病理性瘢痕Key words
transforming growth factor-β1/ β-catenin/ pathological scars分类
医药卫生引用本文复制引用
耿祎楠,郭澍,程铭..正常皮肤组织和病理性瘢痕中转化生长因子β1及β-连环蛋白基因的表达[J].中国医科大学学报,2011,40(12):1131-1133,3.
