中国药理学通报2012，Vol.28Issue(3)：300-303,4.DOI:10.3969/j.issn.1001-1978.2012.03.002
肿瘤自噬效应及其在非小细胞肺癌分子靶向治疗中的潜在应用
Autophagic effect on tumor and its potential applicationsin non-small cell lung cancer molecular targeted therapy
摘要
Abstract
Now clinical treatments for non-small cell lung cancer ( NSCLC ) such as surgery, radiotherapy, and chemotherapy are still insufficient, and the efficacy of some molecular targeted therapy is also limited because of natural and acquired resistance in clinics. Autophagy exhibited the effects of a double-blade sword on tumor progression. On the one hand, autophagic can induce the death of tumor cells, and on the other hand, it alsoprotects the tumor in stress such as nutritional deficiency. Clinical treatment of NSCLC at various stages should take full account of autophagic effect on its progression, which can improve the clinical efficacy of various treatments by reasonable combination.关键词
自噬/肿瘤/分子靶向治疗/NSCLC/信号通路/mTORKey words
autophagy/ cancer/ molecular-targeted therapy/ NSCLC/ signaling pathway/ mTOR分类
医药卫生引用本文复制引用
陈美娟,詹瑧,张旭..肿瘤自噬效应及其在非小细胞肺癌分子靶向治疗中的潜在应用[J].中国药理学通报,2012,28(3):300-303,4.基金项目
国家"十一五"科技支撑计划(No 2006BAI11B08-01) （No 2006BAI11B08-01）
江苏省高校优势学科建设工程项目 （）
