中国药理学与毒理学杂志2012，Vol.26Issue(1)：94-98,5.DOI:10.3867/j.issn.1000-3002.2012.01.019
三七总皂苷肠溶胶囊在比格犬体内的药代动力学
Pharmacokinetics of Panax notoginseng saponins enteric-coated capsules in Beagle dogs
摘要
Abstract
OBJECTIVE To investigate pharmacokinetics of Panax notoginseng saponins (PNS) in Beagle dogs. METHODS PNS enteric-coated capsules 86.2 mg·kg-1 and Xueshuantong capsules 111.8 mg·kg-1 were administered to dogs according to an open randomized crossover design. The plasma concentration of notoginsenoside R,, ginsenoside Rg, and Rbj was determined by RP-HPLC. Pharmacokinetic parameters were calculated by 3P97 software so were those after the integration of blood concentration based on AlIC0→∞. RESULTS Compared with reference preparation, tmax of test preparation R1, Rg1, Rb1 increased; 0. 18 ±0. 09 vs (0. 16 ±0. 06)h for R1, 2. 03 ±0. 76 vs (1. 74 ± 0. 27 ) h for Rg1, 0. 76 ± 0. 39 vs (0. 74 ± 0. 17) h for Rb1; Lag times were prolonged: 0.96 ±0.16 vs (0. 50 ± 0. 11) h for R,, 0. 87 ± 0. 05 vs (0. 02 ± 0. 01) h for Rgl, 0. 92 ± 0.12 vs (0.44 ±0.07) h for Rb^ The relative bioavailability of R,, Rg,, Rb, and PNS was 248.41%, 107. 19% , 152. 94% and 155. 31% , respectively. After integration,the main pharmacokinetic parameters of Xueshuantong capsules and PNS enteric-coated capsules respectively were; AUCq^ 39. 17 ± 3.89 vs (46.91 ±3.86)mg·L-I·-h, Lag times 0.45 ±0. 18 vs (0.93 ±0. 13)h, tmax0.74 ±0. 17 vs (0.77±0.13)h, C/3.84 ±0.24 vs (1.84 ±0.97)L·kg-1·h-1. CONCLUSION PNS enteric-coated capsule can improve the oral bioavailability of PNS.关键词
药代动力学/三七总皂苷/比格犬/血药浓度Key words
pharmacokinetics/Panax notoginseng saponins/Beagle dogs/plasma drug concentration分类
医药卫生引用本文复制引用
秦艳娥,刘华钢,赖玲,陆仕华,文丽,陈明,刘冠萍..三七总皂苷肠溶胶囊在比格犬体内的药代动力学[J].中国药理学与毒理学杂志,2012,26(1):94-98,5.基金项目
广西企业科技特派员专项(桂科攻09321049) （桂科攻09321049）
广西自然科学基金(2010GXNSFB013068) （2010GXNSFB013068）
