中国药业2012，Vol.21Issue(6)：29-30,2.
芥子气诱导真皮成纤维细胞分泌肿瘤坏死因子相关凋亡诱导配体的时效和量效研究
Study on Aging and Doseeffect of TRAIL stimulated by Sulfur Mustard in Dermal Fibroblasts
杨积顺 1徐立平 1胡晋红2
作者信息
- 1. 中国人民解放军第100医院药械科,江苏苏州,215007
- 2. 第二军医大学上海长海医院药学部,上海,200433
- 折叠
摘要
Abstract
Objective To explore the rule of secretion of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) stimulated by sulfur mustard in dermal fibroblasts. Methods The ELISA method was used to detect the relationship between dose and efficacy and between time course and efficacy of TRAIL secretion adjusted by sulfur mustard. Results Dermal fibroblasts could secret certain amount of TRAIL, after sulfur mustard action, the secretion of TRAIL was significantly up - regulated with the time dependence and dose dependence (P < 0. 05). Conclusion The therapeutic mechanism of sulfur mustard for treating psoriasis might related with the promotion of the secretion of TRAIL.关键词
肿瘤坏死因子相关凋亡诱导配体/银屑病/芥子气/凋亡Key words
TNF - related apoptosis - inducing ligand (TRAIL)/ psoriasis/ sulfur mustard/ apoptosis分类
医药卫生引用本文复制引用
杨积顺,徐立平,胡晋红..芥子气诱导真皮成纤维细胞分泌肿瘤坏死因子相关凋亡诱导配体的时效和量效研究[J].中国药业,2012,21(6):29-30,2.
