中国中医药信息杂志2011，Vol.18Issue(12)：14-16,3.DOI:10.3969/j.issn.1005-5304.2011.12.006
类风湿关节炎骨代谢变化及清热解毒方药的干预作用
Bone Metabolism of Rheumatoid Arthritis and Intervention of Heat-clearing and Toxicity-relivingDrug
郭明阳 1罗勇 1刘德芳 1张俊 1郭玲林 1贠明东 1晏蛟1
作者信息
- 1. 中国人民解放军成都军区总医院,四川成都610083
- 折叠
摘要
Abstract
Objective To observe the characteristics of bone metabolism of activity rheumatoid arthritis (RA) and the intervention of heat-clearing and toxicity-reliving drug. Methods One hundred and five cases of activity RA was randomly divided into treatment group (n - 54) and control group (n = 51). In addition, 50 healthy controls matched in age and sex were as healthy group. The control group used MTX as basic medicine, while the treatment group was given heat-clearing and toxicity-reliving herbs-quick acting potion for heat rigon additionally, for three months. The number and level of pain and swell of joint, morning stiffness, rest pain, condition valuation by doctor, and ESR, CRP, BAP, TRACP5b were observed before and after treatment. Results BAP and TRACP5b of RA patients were significantly higher than the healthy (P<0.05). After treatment, the level of BAP and TRACP5b of treatment group decreased significantly (P<0.05), while that of control group declined, but without significance (P>0.05). There was significant difference between the two groups (P<0.05). Conclusion Activity RA has high level of both bone formation and resorption, but bone resorption plays a more important role. The treatment of heat-clearing and toxicity-reliving can reduce BAP and TRACP5b of RA by suppressing bone damage.关键词
类风湿关节炎/清热解毒/骨特异性碱性磷酸酶/抗酒石酸酸性磷酸酶Key words
rheumatoid arthritis/ heat-clearing and toxicity-reliving/ BAP/ TRACP5b分类
医药卫生引用本文复制引用
郭明阳,罗勇,刘德芳,张俊,郭玲林,贠明东,晏蛟..类风湿关节炎骨代谢变化及清热解毒方药的干预作用[J].中国中医药信息杂志,2011,18(12):14-16,3.
