中国中医药信息杂志2011，Vol.18Issue(12)：34-35,38,3.DOI:10.3969/j.issn.1005-5304.2011.12.013
强心复脉颗粒对兔慢性窦房结损伤模型心律的影响
Effect of Qiangxin Fumai Granule on Cardiac Rhythm of Sinoatrial Node with Chronic Injury inRabbits
摘要
Abstract
Objective To study the effect of Qiangxin Fumai granule on cardiac rhythm of the sinoatrial node with chronic injury in rabbits. Methods Sixty healthy adult big ears white rabbits were randomly divided into 6 groups: the normal group, the model group, the atropine group, the high-dose Qiangxin Fumai Granule group, the middle-dose Qiangxin Fumai Granule group and the low-dose Qiangxin Fumai Granule group, with five animals in each group. The rabbit model was established by injecting formaldehyde to the sinoatrial node except the normal group. After the model established, the rabbits received intragastric administration for 7 days, the changes of heart rate at different phases were measured. Results Compared with the normal group, the heart rate in the model group, the atropine group, the high-dose Qiangxin Fumai granule group, the middle-dose Qiangxin Fumai Granule group and the low-dose Qiangxin Fumai granule group were slowed significantly (P<0.05 or P<0.01). Compared with the model group, the heart rate in four treatment groups was accelerated significantly, and the high-dose Qiangxin Fumai Granule group. Was superior to the atropine group (P<0.05). Conclusion Qiangxin Fumai granule can accelerate the heart rate and is beneficial for recovery of sinus node function so as to treat the sick sinus syndrome.关键词
强心复脉颗粒/慢性窦房结损伤/病态窦房结综合征/兔Key words
Qiangxin Fumai granule/ chronic sinoatrial node injury/ sick sinus syndrome/ rabbits分类
医药卫生引用本文复制引用
刘如秀,王妮娜,李汇博,暴美静,汪艳丽..强心复脉颗粒对兔慢性窦房结损伤模型心律的影响[J].中国中医药信息杂志,2011,18(12):34-35,38,3.基金项目
国家自然科学基金(30873332) （30873332）
