中国中医药信息杂志2011，Vol.18Issue(12)：39-42,4.DOI:10.3969/j.issn.1005-5304.2011.12.015
水芹提取物对氢化可的松致肾阳虚小鼠的对抗作用
Effect of Extract of Oenanthe Javanica against Kidney Yang Deficiency in Mice Caused bHydrocortisone
摘要
Abstract
Objective To explore the role of extract of Oenanthe Javanica (OJE) against the deficiency of kidney yang in mice. Methods The male and female mice were randomly divided into six groups: normal group, model group, positive control group and OJE large, medium and small dose group. The normal group were daily injected intraperitoneally with normal saline, and other groups with 25 mg/kg hydrocortisone. At the same time, normal group and model group were given saline, other groups were given drugs at the dose of 0.2 mL/10 g, once a day, for ten days. cAMP, cGMP, sex hormone, MDA and SOD in the serum were determined. Results Compared with the normal group, male of the model group showed strong symptoms of deficiency of kidney yang, locomotor activity decreased significantly (P<0.01), cAMP decreased, cGMP increased, cAMP/cGMP ratio decreased significantly (P < 0.05), testosterone level decreased significantly (P < 0.05), MDA significantly increased (P<0.05), and SOD significantly improved (P<0.05). Yang defciency model was established successfully. However, female of the model group showed no obvious symptoms and no significant changes in each index. Compared with the model group, OJE could significantly alleviate the yang deficiency symptoms of male mice, increase locomotor activity, increase cAMP, decrease cGMP, increase cAMP/cGMP, increase testosterone level, lower MDA concentration and increase SOD activity. OJE played a little role in all the indicators of the female mice, but without statistical significance. Conclusion OJE can significantly treat the yang deficiency symptoms of mice caused by hydrocortisone. Regulating cAMP/cGMP balance, improving the status of the body free radicals and regulating the level of sex hormones may be its mechanism.关键词
水芹提取物/肾阳虚/氢化可的松/小鼠Key words
extract of Oenanthe Javanica/ deficiency of kidney yang/ hydrocortisone/ mice分类
医药卫生引用本文复制引用
苏成虎,杨新波,黄正明,陈晓农,陈红艳,程丽娟,于珊,徐雪钰..水芹提取物对氢化可的松致肾阳虚小鼠的对抗作用[J].中国中医药信息杂志,2011,18(12):39-42,4.基金项目
全军"十一五"新药专项(20082041) （20082041）
