摘要
Abstract
Objective To establish the quality standard for Tongxuanlifei Granules (Hydrochloric acid ephedrine & Hydrochloric acid pseudoephedrine). Methods The contents of Hydrochloric acid ephedrine and Hydrochloric acid pseudoephedrine were determined on the Phenomenex Synerg 4u Polar-RP 80A (250 mm× 4.6 mm, 4 μm) column, with MeOH :0.092% Phosphoric acid solution (with 0.04% Triethylamine and 0.02% Two butyl amine)=l : 99 elution as mobile phase and detective wavelength at 210 nm. Results The average recovery of Hydrochloric acid ephedrine of there concentration was 102.44%, 100.93%, 97.73%, and RSD was 1.30%, 0.38%, 1.77% (n=3). The average recovery of Hydrochloric acid pseudoephedrine was 99.98%, 96.01%, 100.91%, and RSD was 1.65%, 0.65%, 1.91% (n=3). The detection quantity should be within 0.6 - 3 mg labeled weight. Conclusion The method is simple, reliable, accurate and can be applied to the quality control of Tongxuanlifei Granules.关键词
通宣理肺颗粒/盐酸麻黄碱/盐酸伪麻黄碱/质量标准/高效液相色谱法Key words
Tongxuanlifei Granules/ Hydrochloric acid ephedrine/ Hydrochloric acid pseudoephedrine/ quality standard/ HPLC分类
医药卫生
