中国中医药信息杂志2012，Vol.19Issue(1)：45-46,49,3.DOI:10.3969/j.issn.1005-5304.2012.01.016
消风Ⅱ号胶囊对佐剂性关节炎大鼠炎性组织中前列腺素E2及一氧化氮含量的影响
Effect of Xiaofeng Ⅱ Capsule on PGE2 and NO Content of Inflammatory Organization in Adjuvant Arthritis Rats
摘要
Abstract
Objective To investigate the mechanism of Xiaofeng Ⅱ capsule for rheumatoid arthritis by studying the effect of Xiaofeng II capsule on PGE2 and NO content of inflammatory organization in adjuvant arthritis (AA) rats. Methods AA rats were divided randomly into model group, low-dosage (188 mg/kg) of Xiaofeng Ⅱ capsule group (low-dosage group), high-dosage (375 mg/kg) of Xiaofeng II capsule group (high-dosage group) and normal group. After inducing inflammation, AA rats were gastric perfused on the seventh day with Xiaofeng Ⅱ capsule of 1.0 mL/100 g, and with distilled water of equal volume in model group, continuously for 21 days. Executed the rats to measuring PGE2 and NO content of inflammatory organization in AA rats the second day after the last medication. Results Either low-dosage group or high-dosage group could restrain PGE2 biosynthesis of inflammatory organization in the side of injected adjuvant, the inhibition rate was 41.2% and 33.6% respectively. The two groups could restrain NO content of inflammatory organization in the side not injected adjuvant, the inhibition rate was 39.9% and 29.7% respectively. Compared with model group, differences had statistical significance (P < 0.001, P < 0.01). Conclusion The mechanism of Xiaofeng Ⅱ capsule for arthritis is that it can reduce PGE2 and NO content of local inflammatory organization by restraining the biosynthesis of PGE2 and NO or restraining the release of them.关键词
佐剂性关节炎/前列腺素E2/一氧化氮/消风Ⅱ号胶囊/大鼠Key words
rheumatoid arthritis/ PGE2/ NO/ Xiaofeng Ⅱ capsule/ rats分类
医药卫生引用本文复制引用
万强,高波,裴正学,江秀娟,郭红云,李德杏,梁涛,张永东,李雪萍,胡清荣..消风Ⅱ号胶囊对佐剂性关节炎大鼠炎性组织中前列腺素E2及一氧化氮含量的影响[J].中国中医药信息杂志,2012,19(1):45-46,49,3.基金项目
甘肃省中医药管理局资助项目(2005-GKS-10) （2005-GKS-10）
