中国中医药信息杂志2012，Vol.19Issue(2)：28-29,2.DOI:10.3969/j.issn.1005-5304.2012.02.011
含碘中药复方对实验性自身免疫性甲状腺炎血清抗体的影响
Effects of Traditional Chinese Complex Prescription Containing Iodine on Serum Antithyroid Antibodies of Experimental Autoimmune Thyroiditis Rats
摘要
Abstract
Objective To investigate the effects of the traditional Chinese complex prescription containing various doses of iodine in treating experimental autoimmune thyroiditis (EAT) rats by observing serum anti-thyroid antibodies and the weight of thyroid. Methods An animal model of EAT rats was developed by injecting thyroglobulin mixed with complete Ireund's adjuvant immunization and incomplete Freund's adjuvant immunization, and feeding with high iodine water. All the rats were divided into four groups randomly: EAT group, the low-dosage, medium-dosage, and high-dosage of Chinese prescription group. After six weeks' treatment, all rats were dissected, blood were collected, the levels of TgAb, TPOAb and the weight of thyroid (thyroid/body) were detected The results were compared with normal group. Results The levels of serum anti-thyroid antibodies of all groups were significantly lower than that of EAT group. The thyroid weight index of EAT group was higher than that of normal group. The thyroid weight index of all treatment groups were lower than that of EAT group. The thyroid weight index of the high-dosage treatment group was lower than that of the low-dosage treatment group (P<0.05). The difference between the medium-dosage treatment group and the high-dosage treatment group was not obvious (P>0.05). Conclusion The mechanism of traditional Chinese complex prescription in treating antoimmune thyroiditis may be related with decreasing the levels of TgAb and TFOAb, and the effect depends on the dosage of iodine.关键词
含碘中药复方/自身免疫性甲状腺炎/甲状腺抗体/甲状腺质量/大鼠Key words
traditional Chinese complex prescription containing iodine/ experimental autoimmune thyroiditis/ thyroid gland autoantibody/ the weight of thyroid/ rats分类
医药卫生引用本文复制引用
邓翠,张兰,姜维娜,朱小丹,方振伟..含碘中药复方对实验性自身免疫性甲状腺炎血清抗体的影响[J].中国中医药信息杂志,2012,19(2):28-29,2.基金项目
辽宁省科学技术基金(20092038) （20092038）
