姜辛夏颗粒对支气管哮喘大鼠肺组织基质金属蛋白酶及其抑制剂含量的影响OACSCDCSTPCD
Effects of Jiangxinxia Granules on MMP-9 and TIMP-1 Levels in Lung of Bronchial Asthma Rats
目的 观察姜辛夏颗粒对哮喘大鼠肺组织基质金属蛋白酶-9(MMP-9)及其抑制剂-1(TIMP-1)含量的影响,探讨该方对哮喘气道重建的机制.方法将52只雄性SD大鼠随机分为正常组、模型组、地塞米松组、姜辛夏颗粒组.通过皮下和腹腔注射0.2 mL抗原液及反复雾化吸入卵蛋白溶液建立哮喘气道重建动物模型.在哮喘激发2周后行肺组织HE染色观察并检测肺组织MMP-9、TIMP-1含量的变化.结果 大鼠肺组织HE染色显示:模型组肺内支气管黏膜下可见大量炎细胞…查看全部>>
Objective To observe the effect of Jiangxinxia granules on MMP-9 and TIMP-1 levels in lung of asthma rat, and explore its mechanism in airway remodeling. Methods Fifty-two male SD rats wre randomly divided into nornal group, model group, dexamethasone group and Jiangxinxia granules group. The asthmatic airway remodeling model was built by subcutaneous and intraperitoneal injection of 0.2 mL antigen solution as well as repeated inhalation of ovalbumin solutio…查看全部>>
张玉英;何云义;惠朋利;贺鹏;王礼凤;谭颖颖
陕西中医学院,陕西,咸阳,712046陕西中医学院,陕西,咸阳,712046陕西中医学院,陕西,咸阳,712046陕西中医学院,陕西,咸阳,712046陕西中医学院,陕西,咸阳,712046陕西中医学院,陕西,咸阳,712046
医药卫生
支气管哮喘姜辛夏颗粒气道重建基质金属蛋白酶-9基质金属蛋白酶抑制剂-1大鼠
bronchial asthma Jiangxinxia granules airway remodel MMP-9 TIMP-1 rats
《中国中医药信息杂志》 2012 (2)
30-32,3
陕西省专项计划项目(08JK0275)
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