中华医学杂志（英文版）2012，Vol.125Issue(4)：569-573,5.DOI:10.3760/cma.j.issn.0366-6999.2012.04.002
Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population
Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population
CHO Doo-Yeoun 1KIM Kyu-Nam 1KIM Kwang-Min 1LEE Duck-Joo 1KIM Bom-Taeck1
作者信息
- 1. Department of Family Practice & Community Health, Ajou University School of Medicine, Korea
- 折叠
摘要
Abstract
Background The association of emerging biomarkers such as high-sensitivity C-reactive protein (hs-CRP),homocysteine and fibrinogen with the risk of coronary artery disease (CAD) is still uncertain in Asian population including Koreans and little is known about the combined effect of biomarkers on the risk of CAD.Methods A total of 10 650 subjects (6538 men and 4112 women) were enrolled in this study.A 10-year CAD risk was calculated using Framingham risk score modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel Ⅲ (ATP Ⅲ ) and levels of circulating hs-CRP,homocysteine and fibrinogen were measured using validated assays.Results The 10-year CAD risk gradually augmented with increase in the circulating levels of hs-CRP,homocysteine and fibrinogen.For the highest quartile of hs-CRP,odds ratio (OR) of high-risk for CAD (10-year risk ≥20％) compared with the lowest quartile was 3.97 (95％ C/:2.51-6.29).For homocysteine and fibrinogen,ORs in the highest quartile compared to the lowest quartile were 5.10 (95％ Cl:3.05-8.53,P ＜0.001) and 1.46 (95％ Cl:0.69-3.11,P=0.325),respectively.OR of high-risk for CAD in both the highest quartile of hs-CRP and homocysteine was 9.05 (95％ CI:5.30-15.45) compared with the below median of hs-CRP and homocysteine.Conclusions The present study demonstrated that hs-CRP and homocysteine are well associated with the 10-year CAD risk estimated using NCEP ATP Ⅲ in Koreans and combination of hs-CRP and homocysteine can have strong synergyin predicting the development of CAD.关键词
C-reactive protein/homocysteine/fibrinogen/coronary artery diseaseKey words
C-reactive protein/homocysteine/fibrinogen/coronary artery disease引用本文复制引用
CHO Doo-Yeoun,KIM Kyu-Nam,KIM Kwang-Min,LEE Duck-Joo,KIM Bom-Taeck..Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population[J].中华医学杂志（英文版）,2012,125(4):569-573,5.
