首页|期刊导航|中华医学杂志（英文版）|Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
中华医学杂志（英文版）2012，Vol.125Issue(4)：622-625,4.DOI:10.3760/cma.j.issn.0366-6999.2012.04.012
Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese
摘要
Abstract
Background Genetic association studies on populations of European origin have identified the DCDC2 gene as a susceptibility locus for developmental dyslexia.Here,we sought to investigate the association of DCDC2 polymorphisms with developmental dyslexia in children of Han Chinese origin.Methods We undertook a case-control genetic association study on 76 dyslexic children and 79 non-dyslexic matched controls.We isolated DNA from oral mucosal cell samples and genotyped two DCDC2 coding-sequence single nucleotide polymorphisms,rs2274305 and rs6456593,in each sample using SNaPshot single nucleotide extension.We compared the allele and genotype frequencies between the groups using the X2 test and analyzed the relationship between dyslexia and the polymorphism at both loci using unconditional logistic regression.We also predicted haplotypes and compared their frequencies between the two groups.Results The differences in the genotype distribution and the allelic genes of the two single nucleotide luci of the DCDC2 gene,rs2274305 and rs6456593,between the two dyslexic and non-dyslexic groups were statistically meaningless (P ＞0.05).The differences in the haplotype distributions of the DCDC2 gene between the dyslexic and normal group were statistically meaningless (P ＞0.05).Conclusion The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han Chinese.However,methodological issues may have prevented the detection of oositive associations.关键词
DCDC2/case-control/genetic association studyKey words
DCDC2/case-control/genetic association study引用本文复制引用
ZUO Peng-xiang,WU Han-rong,LI Zeng-chun,CAO Xu-dong,PANG Li-juan,YANG Lan,LIU Fan,ZHAO Feng..Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese[J].中华医学杂志（英文版）,2012,125(4):622-625,4.基金项目
This study was supported by grants from the National Natural Science Foundation of China (No.81060239 and No.30872132). （No.81060239 and No.30872132）
