首页|期刊导航|中华医学杂志（英文版）|Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011
中华医学杂志（英文版）2012，Vol.125Issue(5)：828-831,4.DOI:10.3760/cma.j.issn.0366-6999.2012.05.018
Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011
Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011
摘要
Abstract
Background Encephalopathy is a common complication of sepsis,and its onset can occur at any stage of sepsis and implies worse prognosis.However,the incidence,epidemiology,and pathogenesis of sepsis-associated encephalopathy remain controversial.The purpose of this study was to investigate the epidemiological features and risk factors for sepsis-associated encephalopathy.Methods Our retrospective study included all patients with sepsis admitted to our intensive care unit from 2008 to 2011.After excluding 91 patients,232 patients were assigned to either a sepsis-associated encephalopathy group or sepsis without encephalopathy group.Between-group differences in baseline patient data including vital signs,disease severity,pathogens,sites of infection,biochemical indicators,and time on a mechanical ventilator,intensive care unit (ICU) stay,and 28-day mortality rate were analyzed.Results The incidence of sepsis-associated encephalopathy was 17.7％.The sepsis-associated encephalopathy group had significantly higher 28-day mortality (56.1％ vs.35.1％; P=0.013),spent a significantly longer time on a ventilator ((8.2±2.2) days vs.(2.9±0.4) days; P=0.021),and had a significantly longer ICU stay ((12.4±2.4) days vs.(7.1±0.6) days;P=0.042).Acute physiology and chronic health evaluation Ⅱ score,Glasgow coma scale,heart rate,blood lactate,serum sodium,platelets,serum albumin,and pH values were related to the presence of encephalopathy.Patients with biliary tract infections and intestinal infections caused by Staphylococcus aureus,Enterococcus faecium,Acinetobacter spp,Pseudomonas aeruginosa,and Stenotrophomonas maltophilia,were more prone to develop sepsis-associated encephalopathy.Conclusions Encephalopathy increases mortality rate in septic patients.Clinical intervention to reduce risk factors and thereby morbidity and mortality depends on a correct understanding of the differences between patients with sepsis and patients with both sepsis and encephalopathy.关键词
sepsis/sepsis-associated encephalopathy/epidemiology/risk factorKey words
sepsis/sepsis-associated encephalopathy/epidemiology/risk factor引用本文复制引用
ZHANG Li-na,WANG Xiao-ting,AI Yu-hang,GUO Qu-lian,HUANG Li,LIU Zhi-yong,Yao Bo..Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011[J].中华医学杂志（英文版）,2012,125(5):828-831,4.基金项目
The study was supported by the grants from the Science and Technology Plan Foundation of Hunan Province (No.2011FJ6030)and the National Clinical Specialty Construction Project of the Health Ministry (No.[2011]1). （No.2011FJ6030）
