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Functional MRI study of mild Alzheimer's disease using amplitude of low frequency fluctuation analysis

XI Qian ZHAO Xiao-hu WANG Pei-jun GUO Qi-hao YAN Chao-gan HE Yong

中华医学杂志（英文版）2012，Vol.125Issue(5)：858-862,5.

中华医学杂志（英文版）2012，Vol.125Issue(5)：858-862,5.DOI:10.3760/cma.j.issn.0366-6999.2012.05.023

Functional MRI study of mild Alzheimer's disease using amplitude of low frequency fluctuation analysis

XI Qian ¹ZHAO Xiao-hu ¹WANG Pei-jun ¹GUO Qi-hao ²YAN Chao-gan ³HE Yong³

作者信息

1. Department of Radiology, Tongji Hospital of Tongji University,Shanghai 200065, China
2. Department of Neurology, Huashan Hospital of Fudan University,Shanghai 200040, China
3. State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University, Beijing 100875, China
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摘要

Abstract

Background Previous studies have shown that the functional brain activity in the resting state is impaired in Alzheimer's disease (AD) patients.However,most studies focused on the relationship between different brain areas,rather than the amplitude or strength of the regional brain activity.The purpose of this study was to explore the functional brain changes in AD patients by measuring the amplitude of the blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals.Methods Twenty mild AD patients and twenty healthy elderly subjects participated in the fMRI scan.The amplitude of low frequency fluctuation (ALFF) was calculated using REST software.Results Compared with the healthy elderly subjects,the mild AD patients showed decreased ALFF in the right posterior cingulate cortex,right ventral medial prefrontal cortex,and in the bilateral dorsal medial prefrontal cortex.No brain region with increased ALFF was found in the AD group compared with the control group.Conclusions The reduced activity in the posterior cingulate cortex and medial prefrontal cortex observed in the present study suggest that the functional abnormalities of those areas are at an early stage of AD.The ALFF analysis may provide a useful tool in fMRI study of AD.

关键词

Alzheimer's disease/resting-state functional MRI/amplitude of low frequency fluctuation

Key words

Alzheimer's disease/resting-state functional MRI/amplitude of low frequency fluctuation

引用本文复制引用

XI Qian,ZHAO Xiao-hu,WANG Pei-jun,GUO Qi-hao,YAN Chao-gan,HE Yong..Functional MRI study of mild Alzheimer's disease using amplitude of low frequency fluctuation analysis[J].中华医学杂志（英文版）,2012,125(5):858-862,5.

基金项目

This work was supported by grants from the National Natural Science Foundation of China (No.30970818),and the National High-Tech Research and Development Program of China (No.2008AA02Z302). （No.30970818）

中华医学杂志（英文版）

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ISSN：0366-6999

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