中华医学杂志（英文版）2012，Vol.125Issue(5)：920-925,6.DOI:10.3760/cma.j.issn.0366-6999.2012.05.033
Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group
Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group
CAO Shang 1LUO Peng-fei 1LI Wei 1TANG Wan-qin 1CONG Xiao-na 1WEI Ping-min1
作者信息
- 1. Department of Epidemiology and Health statistics, School of Public Health, Southeast University, Nanjing, Jiangsu 210009,China
- 折叠
摘要
Abstract
Background In epidemiological studies,tuberculosis (TB) appears intimately with vitamin D insufficiency whereas its relationship with vitamin D receptor (VDR) polymorphism caused by radical difference remains unspecified.This study aimed to investigate the relationship between vitamin D genetic polymorphism and tuberculosis in Han ethnic group.Methods Meta-analysis was adopted in the synthetic quantitative analysis of documents home and abroad on the relationship between vitamin D genetic polymorphisms and tuberculosis,which were openly published during June 2000 to January 2010.Random effect model and fixed effect model analyses were used to calculate the incorporated odds ratio (OR) based on the heterogeneity test data.Results A total of 6 eligible studies were included in this analysis.The Fokl-ff genotype showed a significant marginal association (Fixed effect model:OR 1.91,95％ CI 1.44-2.52; Random effect model:OR 1.91,95％ CI 0.94-3.88),yet Taql polymorphisms was not significantly related to TB.Conclusion The interaction between FoKI genotype polymorphism and TB observed demonstrates that vitamin D deficiency might exist as a risk factor during the development of TB in Han ethnic group and more evidences needed to validate the conclusion.关键词
vitamin D receptor/tuberculosis/polymorphism/susceptibility/meta-analysisKey words
vitamin D receptor/tuberculosis/polymorphism/susceptibility/meta-analysis引用本文复制引用
CAO Shang,LUO Peng-fei,LI Wei,TANG Wan-qin,CONG Xiao-na,WEI Ping-min..Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group[J].中华医学杂志（英文版）,2012,125(5):920-925,6.
