针灸临床杂志2011，Vol.27Issue(12)：49-52,4.
针刺对更年期脑缺血大鼠GFAP和OX42表达的影响
The Effect of Acupuncture on GFAP and OX42 Expression of Rats with Climacteric Cerebral Ischemia
摘要
Abstract
Objective:To research the influence of GFAP and 0X42 protein expression of MCAO climacteric female rats by electro - acupuncture, and investigate the protective effect of neurological damage and possible mechanisms. Methods: Healthy naturally climacteric female SD rats, use intraluminal MCAO rat model, after the electroacupuncture treatment, Experiments were carried out after the modeling 24 h and 7 d. Neurological signs by Bederson neurological score behavioral changes were observed; Use light microscope morphological changes in brain tissue; It was detected by immunohistochemistry in brain tissue GFAP, 0X42 expression. Results: Electroacupuncture can be significantly improved after cerebral ischemia in rats 7 d or 24 h symptoms of nerve injury; It could improve the pathological brain damage state and reduce varying degrees of the protein expression of GFAP and 0X42 in 7 d and 24 h ischemic brain tissue. Compared with model group, there were significant differences(P < 0.05 or P < 0.01). Conclusion:The electroacupuncture can significantly improve the state of brain tissue pathological damage, and improve after MCAO in rats 7 d or 24 h and symptoms of neurological damage. Electroacupuncture can be through activation Inhibition of glial cells the GFAP and 0X42,24 h and 7 d after ischemia, and inhibit the post - ischemic 24 h and 7 d inflammatory cascade. Reduce the blood - brain barrier, damage so as to improve brain histopathological damage. It plays a positive role in brain protection.关键词
针刺/脑缺血/GFAP/OX42Key words
Acupuncture/Cerebral ischemia/GFAP/0X42分类
医药卫生引用本文复制引用
韩玉生,宫鑫梅,孙洪恩,白巍,李树学,肖洪彬,徐强..针刺对更年期脑缺血大鼠GFAP和OX42表达的影响[J].针灸临床杂志,2011,27(12):49-52,4.基金项目
黑龙江省中医管理局课题,编号:20081112 （）
黑龙江省教委基金项目,编号:10551290. （）
