浙江医学2012，Vol.34Issue(4)：247-249,3.
过氧化物酶体增殖物激活受体基因Pro12Ala多态性与老年OSAHS的相关性研究
Association of PPARG2 (Pro12Ala) gene polymorphism with obstructive sleep apnea-hypopnea syndrome in the elderly patients
摘要
Abstract
To investigate the association between Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma2(PPARG2) gene and obstructive sleep apnea-hypopnea syndrome(OSAHS) in elderly patients. Polymerase chain reaction- based restriction fragment length polymorphism (PCR-RFLP) was used to determine the distribution of allele and genotype frequencies of Prol2Ala polymorphism in PPARG2 gene in 100 patients aged ≥60 y with OSAHS and 40 patients aged ≥60 y with simple snoring(control group).ResultsThe PP.PA an d AA genotype frequencies of Prol2Ala poly-morphism in OSAHS and control group were 93.0% ,7.0% ,0% and 87.5%, 12.5% ,0% respectively. Frequencies of P allele and A allele were 96.5% vs 93.75% and 3.5% vs 6.25% in OSAHS and control groups respectively. There were no significant differences in genotype and allele frequencies between two groups(P >0.05).Pro12Ala polymorphism in PPARG2 gene is not significantly associated with OSAHS in the elderly population.关键词
睡眠呼吸暂停/阻塞性/过氧化物酶体增殖物激活型受体/多态性/基因Key words
Sleep apnea/Obstructive/Peroxisome proliferator-activated receptor/Polymorphism/Genetic引用本文复制引用
杜坚宗,顾亮,吴金彦,赵恬,唐婷玉,吴文娟,吴健,钦光跃..过氧化物酶体增殖物激活受体基因Pro12Ala多态性与老年OSAHS的相关性研究[J].浙江医学,2012,34(4):247-249,3.基金项目
浙江省医药卫生科学研究基金(2007B17) （2007B17）
