肿瘤防治研究2011，Vol.38Issue(12)：1341-1345,5.DOI:10.3971/j.issn.1000-8578.2011.12.001
Notch信号阻断剂抑制鼻咽癌细胞增殖的作用及机制
Expression and Role of Notch Signaling Pathway in Nasopharyngeal Carcinoma Cells
摘要
Abstract
Objective To investigate the role of the Notch signaling in NPC cells. Methods The expression of Notch receptors was detected in 5-8F cells and CNE-1 cells by Western blot Both of these cancer cells were treated with Notch inhibitor GSIs. The proliferation and apoptosis were observed after treated by GSL Results Notch inhibitor and GSI suppressed the levels of Notch-1, Notch-2 and Notch-4, but not of Notch-3. GSI inhibited NPC cell proliferation by inducing apoptosis. In addition. GSI inhibited the AKT and MEK signaling in these NPC cells. Conclusion NPC cells may up-regulate Notch signaling to maintain their proliferation. Notch signaling pathway may be a new potential target for the treatment of NPC.关键词
鼻咽癌/Notch信号/GSI/AKT/MEKKey words
NPC/ Notch/ GSI/ AKT/ MEK分类
医药卫生引用本文复制引用
陈始明,丁永军,华清泉,陈晨,陶泽璋..Notch信号阻断剂抑制鼻咽癌细胞增殖的作用及机制[J].肿瘤防治研究,2011,38(12):1341-1345,5.基金项目
国家自然科学基金资助项目(30872851,81172569) （30872851,81172569）
武汉市青年晨光计划资助项目(200950431168) （200950431168）
