肿瘤防治研究2011，Vol.38Issue(12)：1385-1388,4.DOI:10.3971/j.issn.1000-8578.2011.12.011
T细胞急性淋巴细胞白血病对肿瘤坏死因子相关的凋亡诱导配体的敏感度研究
Sensitivity of T-cell Acute Lymphoblastic Leukemia to TRAIL Induced Apoptosis
张晓春 1卫雪利 1陈诚1
作者信息
- 1. 750004银川,宁夏医科大学总医院儿科三病区
- 折叠
摘要
Abstract
Objective To observe the sensitivity of T-cell acute lymphoblastic leukemia (T-ALL) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and to discuss the possible mechanism. Methods 3 T-ALL cell lines and a primary cell were used and the expression of TRAIL receptors on the cell surface as well as the viability and apoptosis after incubation with TRAIL were measured. Results Most of the cell lines and the primary leukemia cell were highly resistant to TRAIL primarily owing to low cell-surface expression of death receptors. Conclusion Low expression of cellular surface death receptors might be one of the mechanisms for resistance to TRAIL-mediated cellular immunity.关键词
T细胞急性淋巴细胞白血病/凋亡诱导配体/移植物抗白血病/凋亡Key words
T-ALL/TRAIL/GVL/Apoptosis分类
医药卫生引用本文复制引用
张晓春,卫雪利,陈诚..T细胞急性淋巴细胞白血病对肿瘤坏死因子相关的凋亡诱导配体的敏感度研究[J].肿瘤防治研究,2011,38(12):1385-1388,4.
