T细胞急性淋巴细胞白血病对肿瘤坏死因子相关的凋亡诱导配体的敏感度研究OA北大核心CSCDCSTPCD
Sensitivity of T-cell Acute Lymphoblastic Leukemia to TRAIL Induced Apoptosis
目的 观察T细胞急性淋巴细胞白血病(T-ALL)对肿瘤坏死因子(TNF)相关的凋亡诱导配体(TRAIL)所介导的细胞毒的敏感度,并探讨其机制.方法 以T-ALL细胞株3株及原代细胞为研究对象,通过测定细胞表面TRAIL受体表达、TRAIL作用后细胞的存活率及凋亡,观察T-ALL对TRAIL的敏感性.结果 T-ALL细胞对TRAIL中度至高度耐受,其原因主要是细胞表面凋亡受体表达低下.结论 T-ALL对TRAIL耐受,有可能是T-ALL迅速克隆扩增…查看全部>>
Objective To observe the sensitivity of T-cell acute lymphoblastic leukemia (T-ALL) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and to discuss the possible mechanism. Methods 3 T-ALL cell lines and a primary cell were used and the expression of TRAIL receptors on the cell surface as well as the viability and apoptosis after incubation with TRAIL were measured. Results Most of the cell lines and the primary leukemia c…查看全部>>
张晓春;卫雪利;陈诚
750004银川,宁夏医科大学总医院儿科三病区750004银川,宁夏医科大学总医院儿科三病区750004银川,宁夏医科大学总医院儿科三病区
医药卫生
T细胞急性淋巴细胞白血病凋亡诱导配体移植物抗白血病凋亡
T-ALLTRAILGVLApoptosis
《肿瘤防治研究》 2011 (12)
1385-1388,4
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