肿瘤防治研究2011，Vol.38Issue(12)：1397-1400,4.DOI:10.3971/j.issn.1000-8578.2011.12.014
AnnexinⅡ、S100A4在甲状腺乳头状癌中的表达及意义
Expressions and Clinical Significance of Annexin Ⅱ and S100A4 in Papillary Thyroid Carcinoma
黄器伟 1李道明 1黄培 1杨麟珂1
作者信息
- 1. 450052郑州,郑州大学第一附属医院病理科
- 折叠
摘要
Abstract
Objective To investigate the expression of Annexin II and S100A4 in papillary thyroid carcinoma and their correlations with the occurrence and lymphatic metastasis of papillary thyroid carcinoma. Methods The immunohistochemistry S-P and in situ hybridization technique was used to test the different expressions of AnnexinII ,S100A4 proteins and Annexin II Mrna in tissues of 50 papillary thyroid carcinoma, 14 thyroid adenoma,26nodular goiter and 10 normal thyroid gland Results The positive expression rates of Annexinll ,S100A4 proteins and Annexinll Mrna in papillary thyroid carcinoma were 82.00%(41/50),78. 00% (39/50) and 74. 00% (37/50), respectively. They were significantly higher than those in thyroid adenoma,nodular goiter and normal thyroid gland(P<0. 05). The expression rates of Annexinll ,S100A4 proteins and Annexinll Mrna in papillary thyroid carcinoma were associated with lymph node metastasis(F<0. 05). The expression of Annexinll protein was positive correlated with that of S100A4 protein(r= 0. 380,P = 0. 025). The expression of Annexinll protein was positive correlated with that of Annexin II Mrna ( r = 0. 434, P = 0. 008). Conclusion The over expressions of Annexin II and S100A4 were closely related with the occurrence and lymphatic metastases of thyroid carcinoma Combining detection of Annexin II and S1 00A4 would help to distinguish the benign or malignant disease of thyroid gland and predict tumor development and prognosis.关键词
甲状腺乳头状癌/免疫组织化学/原位杂交/AnnexinⅡ/S100A4Key words
Papillary thyroid cancer/Immunohistochemistry)In situ hybridization/ Annexinll /S100A4分类
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黄器伟,李道明,黄培,杨麟珂..AnnexinⅡ、S100A4在甲状腺乳头状癌中的表达及意义[J].肿瘤防治研究,2011,38(12):1397-1400,4.
