肿瘤防治研究2011，Vol.38Issue(12)：1409-1412,4.DOI:10.3971/j.issn.1000-8578.2011.12.017
HIF-1α及转录因子Snail与直肠癌侵袭转移及预后的关系
Expression of Hypoxia-inducible-factor-1α and Transcriptional Factor Snail in Rectal Cancer Induces Metastasis and Poor Prognosis
摘要
Abstract
Objective To investigate the expression of HIF-lo and Snail proteins in rectal cancer and their significance in metastasis and prognosis. Methods The expression of HIF-lot and Snail proteins was detected by using immunohistochemical SABC method in 121 cases of rectal cancer tissues. Results The positive rates of HIF-lct and Snail in rectal cancer were 58. 7%(71/121) and 71. 9%(87/121) .respectively the expression of HIF-la and Snail were significantly related with the lymph node metastasis and TNM stage of rectal cancer (P<0. 05). HIF-lo expression have significantly positive correlation with Snail ex-pression(P<0. 05). Conclusion The overexpression of HIF-la and Snail might be important biological marker for invasion and metastasis and prognosis of rectal carcinoma.关键词
直肠肿瘤/HIF-1α/Snail/肿瘤转移Key words
Rectal cancer/HIF-la/Snail/Neoplasm metastasis分类
医药卫生引用本文复制引用
肖帅,卢先州,刘龙飞,李峰,龙建武..HIF-1α及转录因子Snail与直肠癌侵袭转移及预后的关系[J].肿瘤防治研究,2011,38(12):1409-1412,4.基金项目
衡阳市科技局资助项目(2010kj50) （2010kj50）
