肿瘤防治研究2012，Vol.39Issue(1)：41-43,3.DOI:10.3971/j.issn.1000-8578.2012.01.010
Livin基因在儿童急性白血病中的表达及其意义
Expression and Significance of Livin Gene in Childhood Acute Leukemia
摘要
Abstract
Objective To explore the expression of Livin gene in childhood acute leukemic(CAL) cells and its significance. Methods Semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the mRNA of Livin of CAL, including acute lymphoblastic leukemia(ALL,n = 31) and acute myeloid leukemia (ALL,n= 22) ,and non-leukemia group(n= 12). Results The positive expression rate of Livin mRNA in CAL was 60. 3% ,and that of Livin mRNA in ALL cells and AML cells were 61. 3% and 59. 1 % , respectivel. The difference between them was not significant, but higher than that in control group (8. 3%). And the remission rate of Livin mRNA positive AL children was lower than that of Livin mRNA negative children. Conclusion The overexpression of Livin mRNA plays an important effect on childhood a-cute leukemic, which can be used as one of the parameters in the diagnosis, prediction of recurrence and prognosis of the disease.关键词
Livin基因/儿童/急性白血病/反转录聚合酶链反应Key words
Livin gene/Children/Acute leukemia/Reverse transcriptase polymerase chain reaction分类
医药卫生引用本文复制引用
李建厂,贾秀红,唐慎华,韩琳..Livin基因在儿童急性白血病中的表达及其意义[J].肿瘤防治研究,2012,39(1):41-43,3.基金项目
山东省医药卫生科技发展计划资助项目(2009HW005) （2009HW005）
