肿瘤防治研究2012，Vol.39Issue(1)：44-47,4.DOI:10.3971/j.issn.1000-8578.2012.01.011
Moesin和E-cadherin与甲状腺乳头状癌侵袭的相关性
Correlation of Moesin and E-cadherin with Invasion of Papillary Thyroid Carcinoma
刘畅 1陶晓峰 2高政南 1刘忠1
作者信息
- 1. 116033 辽宁大连,大连市中心医院内分泌科
- 2. 116033 辽宁大连,大连市中心医院病理科
- 折叠
摘要
Abstract
Objective To assess the significance of Moesin and E-cadherin in invasion and metastasis of papillary thyroid carcinoma (PTC). Methods The expressions of Moesin and E-cadherin in 81 cases of PTC and normal thyroid tissues adjacent to cancer were analyzed by immunohistochemical staining. The correlation between these 2 factors(Moesin,E-cadherin)and clinical features of PTC such as gender,age.tumor size,invasion and lymph node metastasis were studied. Results The rates of immuno-positive staining of Moesin and E-cadherin in PTC were significantly higher than that in the normal thyroid tissues adjacent to cancer (P<0. 01). The positive expression rates of Moesin in PTC with age≥45 years,local invasion, lymph node metastasis and in stage Ⅲ ~Ⅳ was higher than PTC with age<45 years, without local invasion,without metastasis and in stageⅠ ~Ⅱ. There was significant difference, respectively(P<0. 01). The positive expression rates of E-cadherin in PTC with age≥45 years,local invasion,lymph node metastasis and in stage Ⅲ-Ⅳ was lower than PTC with age <45 years, without local invasion,without metastasis and in stage Ⅰ ~Ⅱ . There was significant difference,respectively(P<0. 01). There was correlation between the expressions of Moesin and E-cadherin in PTC(r = - 0. 494,P<0. 01). Conclusion The high expressions of Moesin and the low expression of E-cadherin were related to invasion and metastasis of PTC. And the 2 factors have cooperative.关键词
甲状腺乳头状癌/膜突蛋白/上皮型钙黏蛋白Key words
Papillary thyroid carcinoma/Moesin/E-cadherin分类
医药卫生引用本文复制引用
刘畅,陶晓峰,高政南,刘忠..Moesin和E-cadherin与甲状腺乳头状癌侵袭的相关性[J].肿瘤防治研究,2012,39(1):44-47,4.
