肿瘤防治研究2012，Vol.39Issue(1)：54-58,5.DOI:10.3971/j.issn.1000-8578.2012.01.014
NDRG-1及MMP-7在肾细胞癌中的表达及意义
Expression and Significance of NDRG-1 and MMP-7 in Renal Cell Carcinoma
摘要
Abstract
Objective To investigate the expression of N-myc down regulated gene-1 (NDRG-1) and matrix met-alloproteinase-7 (MMP-7) in renal cell carcinoma(RCC) .and the relation to clinicopathologic factors and patient prognosis. Methods High sensitive SP immunohistochemistry was used to detect the expressions of NDRG-1 and MMP-7 in 78 cases of renal cell cancer and its adjacent tissues. Results The proportion of NDRG-1 -expressing tumor cells(52.6%) was significantly lower than that of normal cells(100%)(P<(). 05). The abnormal expression of NDRG-1 correlated with tumor size,renal vein tumor thrombus,metastasis,renal pelvis invasion, histological grade and clinical stage(P<0. 05). However, the proportion of MMP-7-expressing tumor cells(55.1%) was significantly higher than that of normal cells (almost no expression). The abnormal expression of MMP-7 correlated with capsular invasion, metastasis, histological grade and clinical stage(P < 0. 05). Negative expression of NDRG1 and positive expression of MMP-7 in RCC were strong predictors of poor prognosis respectively (P = 0.001). There was no correlation between the expression of NDRG-1 and MMP-7 in RCC(rs = -0. 198,P = 0. 082). Conclusion The low expression of NDRG-1 and high expression of MMP-7 correlate with the invasion,metastasis and patient survival. Our results suggest that NDRG1 and MMP-7 may be two potential targets for determining the degree of malignancy, prognosis and early detection of renal cell carcinoma.关键词
肾细胞癌/NDRG-1/MMP-7/免疫组织化学Key words
Renal cell carcinoma/N-myc down regulated gene-1/Matrix metalloproteinase-7/Immunohistochemistry分类
医药卫生引用本文复制引用
张冠军,梁华,王春宝,张学斌,王一理..NDRG-1及MMP-7在肾细胞癌中的表达及意义[J].肿瘤防治研究,2012,39(1):54-58,5.基金项目
陕西省自然科学基金资助项目(2009JM4002) （2009JM4002）
