中国中西医结合杂志2011，Vol.31Issue(12)：1615-1618,4.
脑心通胶囊对急性心肌梗死患者血管内皮功能及梗死面积的影响
Effect of Naoxintong Capsule on the Vascular Endothelial Function and the Infarct Size of Patients with Acute Myocardial Infarction
摘要
Abstract
Objective To observe the effect of Naoxintong Capsule (NC) on the vascular endothelial function and the infarct size of patients with acute myocardial infarction (AMI). Methods One hundred and four patients with AMI were randomly assigned to the NC group (Group A, 36 cases), the Tongguan Capsule group (Group B, 32 cases), and the conventional Western medicine group (Group C, 36 cases). The conventional Western medicine was given to the three groups. NC was additionally given to Group A, and Tongguan Capsule was additionally given to Group B. The therapeutic course for all was 4 weeks. The plasmal nitric oxide (NO), en-dothelin (ET), von Willebrand factor (vWF) were detected in the 3 groups before and after treatment. The inner diameter of brachial artery was examined by ultrasonograph. The flow-mediated dilation (FMD) and the nitroglycer-in-mediated dilation (NMD) were calculated. The ECG QRS integral and the infarct size were assessed. Results There was no significant difference in the vascular endothelial function, ECG QRS integral, or the infarct size a-mong the three groups before treatment (P>0.05). Compared with before treatment, NO and NMD obviously increased after treatment in Group A and Group B, while the vWF and the infarct size obviously decreased in Group A, all showing statistical difference (P<0.05). Compared with those in Group C, the NO, FMD, NMD significantly increased and ET obviously decreased in Group A and B after treatment (P<0.05). The ECG QRS integral and the infarct size also decreased, with statistically significant differences in Group A (P<0. 05). Better effects on improving NO, NMD, and vWF were obtained in Group A than in Group B (P<0.05). Conclusion NC could reduce the infarct size of AMI patients possibly through improving the vascular endothelial function.关键词
脑心通胶囊/急性心肌梗死/内皮功能/梗死面积Key words
Naoxintong Capsule/ acute myocardial infarction/ endothelial function/ infarct size引用本文复制引用
黎丽娴,陈立,赵焕佳,陈伟明,吕文婧,刘淑玲,陈伯钧..脑心通胶囊对急性心肌梗死患者血管内皮功能及梗死面积的影响[J].中国中西医结合杂志,2011,31(12):1615-1618,4.基金项目
2008年步长集团科学基金资助项目 （）
