中国中西医结合杂志2011，Vol.31Issue(12)：1627-1631,5.
中风病气虚证与神经功能缺损程度及远期预后的关系研究
Study on the Correlation between Stroke of Qi Deficiency Syndrome and the Neurological Impairment Degree and Its Long-term Prognosis
摘要
Abstract
Objective To explore the correlation between stroke of qi deficiency syndrome (QDS) and the neurological impairment degree, and to study its correlation between QDS and its long-term prognosis. Methods Recruited were 706 stroke patients with complete clinical information including diagnostic scale scoring of elements such as wind, fire, phlegm, blood stasis, qi deficiency, and yin deficiency, scoring of The National Institutes of Health Stroke Scale (NIHSS) within 72 h from attack, on the 7th, 14th, 28th, and 90th day after attack, and Barthel index (Bl) scoring on the 90th day. They were assigned to the QDS group (330 cases) and the non-QDS group (376 cases). The NIHSS scores at different time points were compared between the two groups using analysis of variance of repeated measure data. The correlation between each syndrome element and the long-term prognosis of stroke was studied using Logistic regression analysis. Results Higher NIHSS score was found in patients of QDS than those of non-QDS at each time point ( P<0. 01). Statistical difference existed in NIHSS score between the two groups at each time point ( P <0. 01, P <0. 05). Besides, NIHSS score decreased gradually as time went by. The occurrence frequencies of blood stasis syndrome and phlegm syndrome were higher at each time point. On the 90th day after attack, 427 patients with Bl ≥95 (accounting for 60%) had favorable prognosis, while279 with Bl <95 (accounting for40%) had unfavorable prognosis. QDS at each time point was negatively correlated with the 90th-day Bl, with the B value being -0. 496, -0. 714, -0. 867, -0. 567, and -0. 764, respectively. Conclusions Stroke patients of QDS had more severe neurological impairment thanthose of non-QDS. Stroke patients of acute-stage QDS was closely correlated with unfavorable prognosis on the 90th day after attack. Early actively invigorating healthy qi plays an important role in improving the long-term prognosis of stroke patients.关键词
中风病/气虚证/神经功能缺损/预后Key words
stroke/ qi deficiency syndrome/ neurological impairment/ prognosis引用本文复制引用
辛喜艳,高颖,马斌,曹克刚..中风病气虚证与神经功能缺损程度及远期预后的关系研究[J].中国中西医结合杂志,2011,31(12):1627-1631,5.基金项目
国家重点基础研究发展计划(973计划)资助项目(No.2003CB517102) （973计划）
国家科技重大专项资助项目(No.2009ZX09502-028) （No.2009ZX09502-028）
国家中医药管理局资助项目(No.200707001) （No.200707001）
