中国中西医结合杂志2012，Vol.32Issue(1)：9-12,4.
补肾调冲法对多囊卵巢综合征患者抗苗勒氏管激素及卵细胞质量的影响
Effects of Shen Invigoration and Chong Regulating Method on Anti-Mūllerlan Hormone and Oocyte Quality in Polycystic Ovarian Syndrone Patients
摘要
Abstract
Objective To study the effects of Shen Invigorating and Chong-channel Regulating Method (SCRM) on anti-Miillerian hormone (AMH) and its correlation with oocyte quality in the serum and the follicular fluid of infertile patients with polycystic ovarian syndrome (PCOS) who received in vitro fertilization (IVF), thus studying the mechanism of SCRM on the oocyte quality of PCOS patients. Methods Sixty infertile patients with PCOS undergoing in vitro fertilization and embryo transfer (IVF-ET) were randomly assigned to two groups, 30 in each. Erzhi Tiangui Granule combined with Western medicine was given to patients in the treatment group, while Western medicine was given to those in the control group. The single oocyte estradiol (E2) level, the resistive Index (Rl), the pulsatility index (PI) of the follicular membrane, the number of harvested oocytes, the high quality oocyte rate, the fertilization rate, the cleavage rate, the high quality embryo rate, and the difference of AMH in the serum and the follicular fluid were observed between the two groups. The correlation tests were performed between the levels of AMH in the serum and the follicular fluid and the rates of high quality oocyte and high quality embryo. Meanwhile, the correlation analysis of the AMH level between the serum and the follicular fluid was also conducted. Results (1) The single oocyte E2 level, the high quality oocyte rate, the fertilization rate, the cleavage rate, the high quality embryo rate were significantly higher in the treatment group than in the control group (P<0. 05). (2) The Rl and the PI of the foJIicular membrane both significantly more decreased in the treatment group than in the control group (P<0. 05). (3) The levels of AMH in the serum and the follicular fluid were obvi-ously lower in the treatment group than in the control group (P<0. 01). The AMM levels in the serum and the follicle fluid were positively correlated. The level of AMH in the follicular fluid was obviously negatively correlated with the high quality oocyte rate and the high quality embryo rate. Conclusions SCRM could improve the oocyte quality of PCOS patients. Its mechanisms were correlated with regulating the AMH levels in the serum and the follicular fluid, adjusting the androgen level, improving the pathophysiological changes of PCOS patients, and activating the ovarian microenvironment. It is necessary to carry out further studies.关键词
补肾调冲法/多囊卵巢综合征/卵细胞质量/抗苗勒氏管激素Key words
Shen Invigorating and Chong-channel Regulating Method/polycystic ovarian syndrome/oocyte quality/anti-Mullerian hormone引用本文复制引用
连方,赵帅..补肾调冲法对多囊卵巢综合征患者抗苗勒氏管激素及卵细胞质量的影响[J].中国中西医结合杂志,2012,32(1):9-12,4.基金项目
国家自然科学基金资助项目(No.30672706,81072836) （No.30672706,81072836）
山东省自然科学基金资助项目(No.ZR58) （No.ZR58）
