中国中西医结合杂志2012，Vol.32Issue(1)：35-38,4.
益气养阴消癥通络方治疗早期糖尿病肾病临床观察
Clinical Observation of Treating Early Diabetic Nephropathy by Qi Supplementing, Yin Nourishing, Blood Stasis Dispersing, Collateral Dredging Recipe
摘要
Abstract
Objective To observe therapeutic effects of qi supplementing, yin nourishing, blood stasis dispersing, collateral dredging recipe (QYBCR) on early diabetic nephropathy ( DN). Methods Seventy-eight early DN patients were randomly assigned to the treatment group (39 cases, treated by QYBCR) and the control group (39 cases, treated by irbesartan). The changes of the therapeutic efficacy, Chinese medicine syndrome scores, urine albumin excretion rate (UAER), serum creatinine (SCr), blood urine nitrogen (BUN), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), and the occurrence of end-point events were observed after one-year treatment. Results The total effective rate in treatment group was 83. 8% (31/37 cases) , which was obviously higher than that in control group (60.5%, 23/38 cases) (P<0.05). After treatment the Chinese medicine syndrome scores were reduced significantly in the treatment group (P<0.05, P<0.01), and showed significant difference when compared with those in the control group (P < 0.05, P < 0.01). Levels of UAER, SCr, BUN, FBG, TC, and TG were (65. 78 ±9.67) μg/mw\, (93.20 ±12.99) Mmol/L, (5. 69 ±1.21) mmol/L, (6.14 ±1.47) mmol/L, (4.85 ±0.83) mmol/L, (1.46 ±0.81) mmol/L after treatment in treatment group. All of them decreased more significantly than before treatment [(161.03 ±20. 01) μg/min, (101.11 ± 14.33) μmol/L, (6.54 ±1.12) mmol/L, (9.27 ±2.32) mmol/L, (6.19 ±2.13) mmol/L, (2.70 ±1.86) mmol/L] (P<0.05, P<0. 01). The aforesaid indices were also improved in the control group after treatment (P<0.05, P< 0.01). The reduction of TC and TG after treatment in the treatment group was more significant [ (5.58 ±1.57) mmol/L, (1.99 ±1.22) mmol/L] (P<0.05). Besides, the incidence rate of end-point events (5.4%, 2/37) (1 year after the development of clinical DN) of the treatment group was slightly lower than that of the control group(10. 5%, 4/38), but with no statistical difference. Conclusion QYBCR combined with Western medicine-based treatment showed better therapeutic efficacy on early DN.关键词
糖尿病肾病/中医药治疗/益气养阴消癥通络方Key words
diabetic nephropathy/traditional Chinese medicine treatment/Qi Supplementing,Yin Nourishing,Blood Stasis Dispersing,Collateral Dredging Recipe引用本文复制引用
王凤丽,陈志强,王月华,张江华,李黎莉,李林林,张雪云..益气养阴消癥通络方治疗早期糖尿病肾病临床观察[J].中国中西医结合杂志,2012,32(1):35-38,4.基金项目
河北省"十一五"支撑计划项目(No.09276101D-27) （No.09276101D-27）
