中国中西医结合杂志2012，Vol.32Issue(1)：39-42,4.
以加味参芪地黄汤为主延缓慢性肾功能衰竭进展的队列研究
A Cohort Study on Delaying the Progress of Chronic Renal Failure Mainly with Modified Shenqi Dihuang
摘要
Abstract
Objective To assess the therapeutic effects of Chinese medicine (CM) treatment mainly by Modified Shenqi Dihuang Decoction (MSDD) in delaying the progress of chronic renal failure (CRF). Methods A prospective cohort method was employed. CRF patients with serum creatinine (SCr) ranging between 133 and 442 pmol/L were recruited. Those in the CM treatment group (61 cases) were treated with MSDD as well as basic treatment of Western medicine, while those in the control group (57 cases) were treated with basic treatment of Western medicine alone. A 2-year follow-up study was carried out. The effects on postponing the progression of CRF were observed mainly from the levels of hemoglobin (HB), plasma albumin (ALB), SCr, estimated glomerularfiltration rate (eGFR), reciprocal slope of serum creatinine (b value), and endpoint events, etc. Results (1) The progression of the renal function; After 24 months of treatment, better therapeutic effects were shown in the CM treatment group than in the control group (P <0. 05), which could be illustrated by decreased SCr levels, increased eGFR levels, and the positive reciprocal slope of SCr (1/SCr) to the time linear regression slope (b value). There were 40 cases (65. 57%) with a reciprocal slope of SCr (b value) 3s 0 (34.43%) and 21 cases with b <0 in the CM treatment group. However, there were 7 cases (12. 28%) with b≥0 and 50 cases (87. 72%) with b <0 in the control group. The difference was statistically significant (P< 0.05). (2) There was no significant difference in HB or ALB between the two groups after 12 months and 24 months of treatment (P>0. 05). (3) Twenty-four months later, there were 6 endpoint events (9. 84%) in the CM treatment group and 9 (15. 79%) in the control group, with insignificant difference( P>0.05). ConclusionMSDD plus basic treatment of Western medicine could delay the progression of CRF patients.关键词
慢性肾功能衰竭/中药治疗/队列研究/加味参芪地黄汤Key words
chronic renal failure/Chinese medicine treatment/cohort study/Modified Shenqi Dihuang Decoction引用本文复制引用
高辉,汪涛,余仁欢,刘美盈,李耀新..以加味参芪地黄汤为主延缓慢性肾功能衰竭进展的队列研究[J].中国中西医结合杂志,2012,32(1):39-42,4.基金项目
中国中医科学院西苑医院科研项目[ No.XYKY-MP(07)-48] （07）
