中国中西医结合杂志2012，Vol.32Issue(1)：43-46,4.
补髓生血颗粒对慢性再生障碍性贫血患者骨髓基质细胞碱性成纤维细胞生长因子及其受体的影响
Effects of Busui Shengxue Granule on bFGF and bFGFR In Bone Marrow Derived Stroma Cells of Chronic Aplastic Anemia Patients
施海涛 1王金环 2孙岸弢 3刘娜 2雍延礼 2孙伟正2
作者信息
- 1. 黑龙江省大庆龙南医院肾内科,黑龙江省大庆市163002
- 2. 黑龙江中医药大学附属第一医院血液科,哈尔滨150040
- 3. 中国中医科学院临床基础医学研究所,北京100700
- 折叠
摘要
Abstract
Objective To observe the therapeutic effects of Busui Shengxue Granule (BSSXG) on chronic aplastic anemia (CAA) patients and its effects on bone marrow derived stroma cells (BMDSCs) correlated cytokines. Methods One hundred and twenty-four patients with CAA were randomly assigned to two groups according to the random digit table. Patients in the test group (61 cases) were treated with BSSXG, while those in the control group (63 cases) were treated with Zaizao Shengxue Tablet (ZST). The therapeutic course was 6 months for all. Besides, 10 healthy subjects were recruited as the normal control group. Changes of the symptom integral, therapeutic efficacy judgment, and changes of peripheral hemogram of patients were observed. The mRNA expression of b-fibroblast growth factors (bFGF) and b-fibroblast growth factors receptor (bFGFR) were detected by reverse transcription PCR. Results The total effective rate of the test group was 75. 0% (45/61), higher than that of the control group (58. 7%, 37/63). Its symptom integral and peripheral hemogram were obviously improved, better than those of the control group (P < 0. 05, P < 0. 01). The mRNA expressions of bFGF and bFGFR of the test group were obviously lower than those of the normal control group (P<0. 05,P<0. 01). They were somewhat improved after treatment in the two groups, with better results obtained in the test group. Conclusions BSSXG showed better clinical effects. It could improve the symptom integral and peripheral hemogram of CAA patients, improve the clinical efficacy, and regulate the expression levels of bFGF and bFGFR. It improved the hematopoietic microenvironment and promoted the hematopoiesis of the bone marrow through regu-lating the proliferation and oriental differentiation of stroma cells, and promoting the bone marrow angiogenesis.关键词
慢性再生障碍性贫血/补髓生血颗粒/细胞因子/成纤维细胞生长因子Key words
chronic aplastic anemia/Busui Shengxue Granule/cytokine/b-fibroblast growth factor引用本文复制引用
施海涛,王金环,孙岸弢,刘娜,雍延礼,孙伟正..补髓生血颗粒对慢性再生障碍性贫血患者骨髓基质细胞碱性成纤维细胞生长因子及其受体的影响[J].中国中西医结合杂志,2012,32(1):43-46,4.
