中国中西医结合杂志2012，Vol.32Issue(1)：58-60,3.
加减温经汤对寒凝血瘀模型大鼠卵巢氧化损伤的影响
Effects of Modified Wenjing Decoction on the Ovarian Oxidative Damage of Cold Coagulation Blood Stasis Model Rats
摘要
Abstract
Objective To observe the effects of Modified Wenjing Decoction (MWJD) on the ovarian oxi-dative damage of cold coagulation blood stasis (CCBS) model rats, thus consummating the action mechanisms of MWJD for treating gynecopathy of CCBS syndrome. Methods Female SD rats were randomly divided into the normal group, the model group, and the treatment group. Rats in the model group and the treatment group were placed in the ice water (0-1 *C) to establish the rat model of CCBS syndrome. Meanwhile, MWJD was given by gastrogavage to rats in the treatment group for 2 weeks. Rats were decapitated during the oestrous cycle. The serum levels of estradiol (E2), progestone (P), testosterone (T) were detected. The bilateral ovarian tissues were taken out and operated on ice. The total bilirubin (TBIL), superoxide dismutase (SOD), malondialdehyde (MDA), total antioxygen capacity (T-AOC) were detected after homogenate. Results Compared with the normal group, serum levels of E2, P, T, and ovarian levels of TBIL, SOD, T-AOC all obviously decreased in the model group, and the ovarian MDA level increased, showing statistical difference (P<0. 05, P<0. 01). After treated by MWJD, when compared with the model group, serum levels of E2, P, T, and ovarian levels of TBIL, SOD, T-AOC increased, the ovarian MDA level decreased, showing statistical difference (P<0. 05, P<0. 01). All indices except serum T level and the ovarian MDA content restored to the normal levels (all P>0. 05). Conclusions The ovarian functions are abnormal in CCBS model rats. MWJD could restore the ovarian functions by improving the ovarian oxidative damage state, thus treating gynecopathy of CCBS syndrome.关键词
加减温经汤/寒凝血瘀模型大鼠/卵巢氧化损伤Key words
Modified Wenjing Decoction/cold coagulation blood stasis model rat/ovarian oxidative damage引用本文复制引用
徐丁洁,杜惠兰,成秀梅,徐洪..加减温经汤对寒凝血瘀模型大鼠卵巢氧化损伤的影响[J].中国中西医结合杂志,2012,32(1):58-60,3.基金项目
国家自然科学基金资助项目(No.30973766 （）
