中国中西医结合杂志2012，Vol.32Issue(1)：61-63,3.
临床高剂量雷公藤多苷对幼年大鼠生育能力的影响
Effects of High Dose Glycosides of Tripterygium wilfordll Hook.f on the Fertility of Young Rats
摘要
Abstract
Objective To explore the effects of high dose glycosides of Tripterygium wilfordii Hook, f (GTW) on the fertility of young rats. Methods Fifty female SD young rats and 50 male SD young rats were randomly divided into the blank group and the GTW group, 25 in each. GTW was given at the daily dose of 9 mg/kg. After 12 weeks of medication, the male rats were caged together with healthy adult female rats in the ratio of 1:1. The female rats were caged together with healthy adult male rats in the ratio of 2:1. The cage process lasted for two weeks, totally for three times. The pregnant rate of female rats and the survival rate of baby rats were then observed. Results There was no significant difference in the pregnant rate or the survival rate of baby rats in the GTW group. Conclusion High dose GTW showed no obvious effects on the fertility of adult rats or the growth and development of new born rats.关键词
雷公藤多苷/幼年大鼠/生育能力Key words
glycosides of Tripterygium wilfordii Hook. F/baby rat/fertility capacity引用本文复制引用
丁樱,马腾,杨晓青,张博..临床高剂量雷公藤多苷对幼年大鼠生育能力的影响[J].中国中西医结合杂志,2012,32(1):61-63,3.基金项目
河南省科技厅科技攻关项目(No.102102310092) （No.102102310092）
