中国中西医结合杂志2012，Vol.32Issue(1)：64-67,4.
四物汤类方与组方药材及其所含主要芳香酸体外抗氧化活性比较与量效关系研究
Comparison of in vitro Anti-oxidative Activities among Siwu Decoction Serial Recipes, Their Composed Crude Herbs, and Main Aromatic Acids, as well as Their Dose-effect Correlation
摘要
Abstract
Objective To assess and compare the in vitro anti-oxidative activities among Siwu Decoction Serial Recipes, their composed crude herbs, and main aromatic acids they contained. Methods Their anti-oxidative activities (including Siwu Decoction and correlated recipes such as Taohong Siwu Decoction, Xiangfu Siwu Decoction, Sha-ofu Zhuyu Decoction, and Xiongqiong Decoction, 16 kinds of crude herbs, and main aromatic acids they contained) were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical clearance method. Results The selected five decoctions showed obvious activities of scavenging free radicals. Siwu Decoction was better than other decoctions in scavenging free radicals and Xiongqiong Decoction was the least. Among the 16 kinds of crude herbs, red peony root, white peony root, safflower, ligustici chuanxiong, common aucklandia root showed the strongest activities, while peach seed showed the poorest activities. Among aromatic acids, gallic acid, protocatechuic acid, vanillic acid, caffeic acid, chlorogenic acid, p-coumaric acid, and ferulic acid showed obvious anti-oxidative activities in scavenging free radicals, showing obvious dose-effect correlation, p-hydroxybenzoic acid, benzoic acid, and cinnamic acid showed no activities on scavenging free radicals (P>0.05). Conclusion Siwu Decoction and aromatic acids contained in correlated decoctions played significant roles in anti-oxidative activities.关键词
四物汤/类方/芳香酸/抗氧化/2,2-二苯基-1-苦肼基Key words
Siwu Decoction/serial decoctions/aromatic acid/anti-oxidative activity/2,2-diphenyl-1-pic-rylhydrazyl引用本文复制引用
唐于平,黄美艳,张彦华,朱敏,刘立,刘培,宿树兰,段金廒..四物汤类方与组方药材及其所含主要芳香酸体外抗氧化活性比较与量效关系研究[J].中国中西医结合杂志,2012,32(1):64-67,4.基金项目
江苏省高校自然科学重大基础研究项目(No.06KJA36022,No.07KJA36024) （No.06KJA36022,No.07KJA36024）
国家科技支撑计划(No.2008BAI51B01) （No.2008BAI51B01）
国家教育部"新世纪优秀人才支持计划"(No.NCET-09-0163) （No.NCET-09-0163）
江苏高等学校优秀科技创新团队支持计划(2009年度) （2009年度）
江苏省方剂高技术研究重点实验室建设项目资助(No.BM2010576) （No.BM2010576）
江苏高校优势学科建设工程资助项目(No.ysxk-2010) （No.ysxk-2010）
