中药材2011，Vol.34Issue(11)：1712-1715,4.
夏枯草迷迭香酸成分分析及其对α-糖苷酶活性影响研究
Analyze on the Component of Rosmarinic Acid in Prunella vulgaris and Its Effect on α-Glycosidase Activity
摘要
Abstract
Objective; To analyze rosmarinic acid in Prunella vulgaris and its effect on the activity of a-gly cosidase. Methods; Q-ualitative and quantitative analyses of Rosmarinic acid in Prunella vulgaris were carried out by HPLC. The activity of different micro reaction systems like a-amylase, a-glucosida.se and a-maltase, which were added to Rosmarinic acid and Acarbose, was determined by Bernfeld, pNPG and GOD. Results; The contents of Rosmarinic acid in the aqueous extract and its dry powder, and extractum of Prunella vulgaris were 0. 1494, 0. 1657 and 0. 2739 mg/g respectively, equal to crude drug. The Rosmarinic acid inhibited a-glycosidase, and its inhibition from a - maltase in small intestine was noncompetitive. Conclusion: The aqueous extract of Prunella vulgaris and its extraction's inhibition from a-glycosidase is related to Rosmarinic acid.关键词
迷迭香酸/α-糖苷酶/酶抑制剂Key words
Rosmarinic acid/ a-glycosidase/ Enzyme inhibitor分类
医药卫生引用本文复制引用
吴慧平,王洪兰,张喆,许婷婷,陈美娟,张旭,戴晓明..夏枯草迷迭香酸成分分析及其对α-糖苷酶活性影响研究[J].中药材,2011,34(11):1712-1715,4.基金项目
国家科技支撑计划"硕导中医药诊疗技术及特色产品应用研究"重点项目(2006BAI11B08) （2006BAI11B08）
中西医结合基础学科资助 （）
